ul_1690----
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PPBD protein
Gene name ITGB1BP1
Synonyms ICAP-1; Integrin cytoplasmic domain-associated protein 1
GO annotations GO_component: membrane [PMID 9281591]
GO_function:protein C-terminus binding [PMID 9281591]
GO_process: cell adhesion [PMID 9281591]; cell-matrix adhesion [PMID 9281591]; protein kinase cascade [PMID 9813144]
RefSeq accession NP_004754
SwissProt accession O14713
Substrate protein
Gene name KRIT1
Synonyms Cerebral cavernous malformations 1 protein; Krev interaction trapped 1
GO annotations GO_component: cytoskeleton
GO_function:acyl-CoA binding; protein binding [PMID 16037064]; small GTPase regulator activity [PMID 9285558]
GO_process: small GTPase mediated signal transduction [PMID 9285558]
RefSeq accession NP_004903
SwissProt accession O00522
Sequence:(RefSeq accession:NP_004903; substrate region highlighted if known)
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MGNPENIEDA YVAVIRPKNT ASLNSREYRA KSYEILLHEV PIEGQKKKRK KVLLETKLQG
NSEITQGILD YVVETTKPIS PANQGIRGKR VVLMKKFPLD GEKMGREASL FIVPSVVKDN
TKYTYTPGCP IFYCLQDIMR VCSESSTHFA TLTARMLIAL DKWLDERHAQ SHFIPALFRP
SPLERIKTNV INPAYATESG QTENSLHMGY SALEIKSKML ALEKADTCIY NPLFGSDLQY
TNRVDKVVIN PYFGLGAPDY SKIQIPKQEK WQRSMSSVTE DKERQWVDDF PLHRSACEGD
SELLSRLLSE RFSVNQLDSD HWAPIHYACW YGKVEATRIL LEKGKCNPNL LNGQLSSPLH
FAAGGGHAEI VQILLNHPET DRHITDQQGR SPLNICEENK QNNWEEAAKL LKEAINKPYE
KVRIYRMDGS YRSVELKHGN NTTVQQIMEG MRLSQETQQY FTIWICSENL SLQLKPYHKP
LQHVRDWPEI LAELTNLDPQ RETPQLFLRR DVRLPLEVEK QIEDPLAILI LFDEARYNLL
KGFYTAPDAK LITLASLLLQ IVYGNYESKK HKQGFLNEEN LKSIVPVTKL KSKAPHWTNR
ILHEYKNLST SEGVSKEMHH LQRMFLQNCW EIPTYGAAFF TGQIFTKASP SNHKVIPVYV
GVNIKGLHLL NMETKALLIS LKYGCFMWQL GDTDTCFQIH SMENKMSFIV HTKQAGLVVK
LLMKLNGQLM PTERNS
Records:
Category Evidence Reference
A Mutagenesis Zhang J, Clatterbuck RE, Rigamonti D, Chang DD, Dietz HC., Interaction between krit1 and icap1alpha infers perturbation of integrin beta1-mediated angiogenesis in the pathogenesis of cerebral cavernous malformation., [11741838]
A Mutagenesis Zawistowski JS, Serebriiskii IG, Lee MF, Golemis EA, Marchuk DA., KRIT1 association with the integrin-binding protein ICAP-1: a new direction in the elucidation of cerebral cavernous malformations (CCM1) pathogenesis., [11854171]
End of Record Details