ul_1693----
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PPBD protein
Gene name LDLRAP1( Description: low density lipoprotein receptor adaptor protein 1. )
Synonyms ARH; ARH1; ARH2; DKFZp586D0624; FHCB1; FHCB2; MGC34705
GO annotations GO_component: AP-1 adaptor complex [PMID 12451172]; AP-2 adaptor complex [PMID 12221107] [PMID 12451172]; basal plasma membrane [PMID 12451172]; cytosol [PMID 12451172]; early endosome [PMID 14528014]
GO_function:clathrin binding [PMID 12451172]; phosphotyrosine binding [PMID 12451172]; protein binding, bridging [PMID 12451172]; protein C-terminus binding [PMID 12221107]; receptor signaling complex scaffold activity [PMID 15166224]; transport accessory protein activity [PMID 12451172]
GO_process: cholesterol homeostasis [PMID 12451172]; cholesterol metabolism [PMID 12451172]; endocytosis; lipid metabolism; positive regulation of receptor mediated endocytosis [PMID 15166224]; regulation of protein binding [PMID 15166224]; steroid metabolism
RefSeq accession NP_056442
SwissProt accession Q5SW96
Substrate protein
Gene name LDLR( Description: low density lipoprotein receptor (familial hypercholesterolemia). )
Synonyms FH; FHC
GO annotations GO_component: coated pit; integral to plasma membrane [PMID 6327078]; plasma membrane [PMID 2777800]
GO_function:calcium ion binding; lipid transporter activity; lipoprotein binding [PMID 6091915]; low-density lipoprotein receptor activity [PMID 2777800]; transmembrane receptor activity [PMID 6091915]
GO_process: cholesterol metabolism; endocytosis [PMID 12671190]; lipid metabolism [PMID 6299582] [PMID 10827173]; lipid transport; protein amino acid O-linked glycosylation [PMID 6091915]; steroid metabolism
RefSeq accession NP_000518
SwissProt accession P01130
GO Pathway:
GO:0006897     endocytosis
Sequence:(RefSeq accession:NP_000518; substrate region highlighted if known)
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MGPWGWKLRW TVALLLAAAG TAVGDRCERN EFQCQDGKCI SYKWVCDGSA ECQDGSDESQ
ETCLSVTCKS GDFSCGGRVN RCIPQFWRCD GQVDCDNGSD EQGCPPKTCS QDEFRCHDGK
CISRQFVCDS DRDCLDGSDE ASCPVLTCGP ASFQCNSSTC IPQLWACDND PDCEDGSDEW
PQRCRGLYVF QGDSSPCSAF EFHCLSGECI HSSWRCDGGP DCKDKSDEEN CAVATCRPDE
FQCSDGNCIH GSRQCDREYD CKDMSDEVGC VNVTLCEGPN KFKCHSGECI TLDKVCNMAR
DCRDWSDEPI KECGTNECLD NNGGCSHVCN DLKIGYECLC PDGFQLVAQR RCEDIDECQD
PDTCSQLCVN LEGGYKCQCE EGFQLDPHTK ACKAVGSIAY LFFTNRHEVR KMTLDRSEYT
SLIPNLRNVV ALDTEVASNR IYWSDLSQRM ICSTQLDRAH GVSSYDTVIS RDIQAPDGLA
VDWIHSNIYW TDSVLGTVSV ADTKGVKRKT LFRENGSKPR AIVVDPVHGF MYWTDWGTPA
KIKKGGLNGV DIYSLVTENI QWPNGITLDL LSGRLYWVDS KLHSISSIDV NGGNRKTILE
DEKRLAHPFS LAVFEDKVFW TDIINEAIFS ANRLTGSDVN LLAENLLSPE DMVLFHNLTQ
PRGVNWCERT TLSNGGCQYL CLPAPQINPH SPKFTCACPD GMLLARDMRS CLTEAEAAVA
TQETSTVRLK VSSTAVRTQH TTTRPVPDTS RLPGATPGLT TVEIVTMSHQ ALGDVAGRGN
EKKPSSVRAL SIVLPIVLLV FLCLGVFLLW KNWRLKNINS INFDNPVYQK TTEDEVHICH
NQDGYSYPSR QMVSLEDDVA
Records:
Category Evidence Reference
A Peptide library He G, Gupta S, Yi M, Michaely P, Hobbs HH, Cohen JC., ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2., [12221107]
End of Record Details