ul_1700----
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PPBD protein
Gene name MAPK8IP2( Description: Tir. )
Synonyms 2.3; 34Ea; BG:DS00941.4; CG10637; CG18250; CG6772; CG7793; CG8200; CK02126; CT41273; DG; DmDG; E(sev)2A; EK2-8; EY2-3; FLO1; FLO[Dm]; RPB1; RPB220; SOS; SUA8; Sos1; Su(tor)2-2; YAP2; br24; br25; d; dSos; dgn; dme-SOS; l(2)34Ea; l(2)br24; l(2)br25; l(2)k05224; l(2)k06321; nak; reggie-2; slob
GO annotations GO_component:
GO_function:
GO_process:
RefSeq accession
SwissProt accession Q13387
Substrate protein
Gene name APP
Synonyms ABPP; APP; APPI; Alzheimer disease amyloid protein; CVAP; Cerebral vascular amyloid peptide; PN-II; PreA4; Protease nexin-II
GO annotations GO_component: cell surface [PMID 7593229]; coated pit; extracellular region [PMID 10806211]; integral to plasma membrane [PMID 10806211]; membrane
GO_function:copper ion binding; heparin binding; iron ion binding; metal ion binding; protein binding [PMID 2119582] [PMID 8626687] [PMID 10049767] [PMID 10081969] [PMID 14557245]; serine-type endopeptidase inhibitor activity [PMID 10652580] [PMID 11279603]; zinc ion binding
GO_process: apoptosis; cell adhesion; copper ion homeostasis [PMID 15910549]; endocytosis; neuromuscular physiological process [PMID 7593229]; Notch signaling pathway
RefSeq accession NP_000475
SwissProt accession P05067
Sequence:(RefSeq accession:NP_000475; substrate region highlighted if known)
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MLPGLALLLL AAWTARALEV PTDGNAGLLA EPQIAMFCGR LNMHMNVQNG KWDSDPSGTK
TCIDTKEGIL QYCQEVYPEL QITNVVEANQ PVTIQNWCKR GRKQCKTHPH FVIPYRCLVG
EFVSDALLVP DKCKFLHQER MDVCETHLHW HTVAKETCSE KSTNLHDYGM LLPCGIDKFR
GVEFVCCPLA EESDNVDSAD AEEDDSDVWW GGADTDYADG SEDKVVEVAE EEEVAEVEEE
EADDDEDDED GDEVEEEAEE PYEEATERTT SIATTTTTTT ESVEEVVREV CSEQAETGPC
RAMISRWYFD VTEGKCAPFF YGGCGGNRNN FDTEEYCMAV CGSAMSQSLL KTTQEPLARD
PVKLPTTAAS TPDAVDKYLE TPGDENEHAH FQKAKERLEA KHRERMSQVM REWEEAERQA
KNLPKADKKA VIQHFQEKVE SLEQEAANER QQLVETHMAR VEAMLNDRRR LALENYITAL
QAVPPRPRHV FNMLKKYVRA EQKDRQHTLK HFEHVRMVDP KKAAQIRSQV MTHLRVIYER
MNQSLSLLYN VPAVAEEIQD EVDELLQKEQ NYSDDVLANM ISEPRISYGN DALMPSLTET
KTTVELLPVN GEFSLDDLQP WHSFGADSVP ANTENEVEPV DARPAADRGL TTRPGSGLTN
IKTEEISEVK MDAEFRHDSG YEVHHQKLVF FAEDVGSNKG AIIGLMVGGV VIATVIVITL
VMLKKKQYTS IHHGVVEVDA AVTPEERHLS KMQQNGYENP TYKFFEQMQN
Records:
Category Evidence Reference
A Peptide library Scheinfeld MH, Roncarati R, Vito P, Lopez PA, Abdallah M, D'Adamio L., Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP)., [11724784]
End of Record Details