ul_1754----
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PPBD protein
Gene name SHC1
Synonyms SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_003020
SwissProt accession P29353
Substrate protein
Gene name Inpp5d( Description: inositol polyphosphate-5-phosphatase D. )
Synonyms 145kDa; AI323613; MGC117680; SHIP; SHIP-1; s-SHIP
GO annotations GO_component:
GO_function:protein binding
GO_process: determination of adult life span; immunoglobulin mediated immune response; intracellular signaling cascade; negative regulation of B cell activation; negative regulation of B cell proliferation; negative regulation of bone resorption; negative regulation of granulocyte differentiation; negative regulation of immune response; negative regulation of interleukin-6 biosynthesis; negative regulation of monocyte differentiation; negative regulation of neutrophil differentiation; negative regulation of osteoclast differentiation; negative regulation of signal transduction; positive regulation of apoptosis; positive regulation of B cell differentiation; positive regulation of erythrocyte differentiation; positive regulation of lymphocyte differentiation
RefSeq accession NP_034696
SwissProt accession Q3UEU0
Sequence:(RefSeq accession:NP_034696; substrate region highlighted if known)
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961
1021
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1141
MPAMVPGWNH GNITRSKAEE LLSRAGKDGS FLVRASESIP RAYALCVLFR NCVYTYRILP
NEDDKFTVQA SEGVPMRFFT KLDQLIDFYK KENMGLVTHL QYPVPLEEED AIDEAEEDTV
ESVMSPPELP PRNIPMSAGP SEAKDLPLAT ENPRAPEVTR LSLSETLFQR LQSMDTSGLP
EEHLKAIQDY LSTQLLLDSD FLKTGSSNLP HLKKLMSLLC KELHGEVIRT LPSLESLQRL
FDQQLSPGLR PRPQVPGEAS PITMVAKLSQ LTSLLSSIED KVKSLLHEGS ESTNRRSLIP
PVTFEVKSES LGIPQKMHLK VDVESGKLIV KKSKDGSEDK FYSHKKILQL IKSQKFLNKL
VILVETEKEK ILRKEYVFAD SKKREGFCQL LQQMKNKHSE QPEPDMITIF IGTWNMGNAP
PPKKITSWFL SKGQGKTRDD SADYIPHDIY VIGTQEDPLG EKEWLELLRH SLQEVTSMTF
KTVAIHTLWN IRIVVLAKPE HENRISHICT DNVKTGIANT LGNKGAAGVS FMFIGTSLGF
VNSHLTSGSE KKLRRNQNYM NILRFLALGD KKLSPFNITH RFTHLFWLGD LNYRVELPTW
EAEAIIQKIK QQQYSDLLAH DQLLLERKDQ KVFLHFEEEE ITFAPTYRFE RLTRDKYAYT
KQKATGMKYN LPSWCDRVLW KSYPLVHVVC QSYGSTSDIM TSDHSPVFAT FEAGVTSQFV
SKNGPGTVDS QGQIEFLACY ATLKTKSQTK FYLEFHSSCL ESFVKSQEGE NEEGSEGELV
VRFGETLPKL KPIISDPEYL LDQHILISIK SSDSDESYGE GCIALRLETT EAQHPIYTPL
THHGEMTGHF RGEIKLQTSQ GKMREKLYDF VKTERDESSG MKCLKNLTSH DPMRQWEPSG
RVPACGVSSL NEMINPNYIG MGPFGQPLHG KSTLSPDQQL TAWSYDQLPK DSSLGPGRGE
GPPTPPSQPP LSPKKFSSST ANRGPCPRVQ EARPGDLGKV EALLQEDLLL TKPEMFENPL
YGSVSSFPKL VPRKEQESPK MLRKEPPPCP DPGISSPSIV LPKAQEVESV KGTSKQAPVP
VLGPTPRIRS FTCSSSAEGR MTSGDKSQGK PKASASSQAP VPVKRPVKPS RSEMSQQTTP
IPAPRPPLPV KSPAVLQLQH SKGRDYRDNT ELPHHGKHRQ EEGLLGRTAM Q
Records:
Category Evidence Reference
A Inference Liu L, Damen JE, Hughes MR, Babic I, Jirik FR, Krystal G., The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of SHIP, its association with Shc, and its induction of apoptosis., [9083021]
End of Record Details