ul_1777----
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PPBD protein
Gene name SHC1
Synonyms SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_003020
SwissProt accession P29353
Substrate protein
Gene name Csf2rb( Description: colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage). )
Synonyms AI848964; AIC2B; Bc; CD131 antigen; CDw131; Csf2rb1; Csfgmrb; GM-CSF/IL-3/IL-5 receptor common beta-chain; Il3r; Il3rb; Il3rb1; Il5rb; MGC130522
GO annotations GO_component: membrane
GO_function:hematopoietin/interferon-class (D200-domain) cytokine receptor activity; interleukin receptor activity; receptor activity
GO_process: cytokine and chemokine mediated signaling pathway
RefSeq accession NP_031806
SwissProt accession P26955
Sequence:(RefSeq accession:NP_031806; substrate region highlighted if known)
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MDQQMALTWG LCYMALVALC WGHGVTEAEE TVPLKTLQCY NDYTNHIICS WADTEDAQGL
INMTLYHQLE KKQPVSCELS EELMWSECPS SHRCVPRRCV IPYTRFSITN EDYYSFRPDS
DLGIQLMVPL AQNVQPPLPK NVSISSSEDR FLLEWSVSLG DAQVSWLSSK DIEFEVAYKR
LQDSWEDAYS LHTSKFQVNF EPKLFLPNSI YAARVRTRLS PGSSLSGRPS RWSPEVHWDS
QPGDKAQPQN LQCFFDGIQS LHCSWEVWTQ TTGSVSFGLF YRPSPVAPEE KCSPVVKEPP
GASVYTRYHC SLPVPEPSAH SQYTVSVKHL EQGKFIMSYN HIQMEPPTLN LTKNRDSYSL
HWETQKMAYS FIEHTFQVQY KKKSDSWEDS KTENLDRAHS MDLSQLEPDT SYCARVRVKP
ISNYDGIWSK WSEEYTWKTD WVMPTLWIVL ILVFLILTLL LILRFGCVSV YRTYRKWKEK
IPNPSKSLLF QDGGKGLWPP GSMAAFATKN PALQGPQSRL LAEQQGESYA HLEDNNVSPL
TIEDPNIIRV PPSGPDTTPA ASSESTEQLP NVQVEGPTPN RPRKQLPSFD FNGPYLGPPQ
SHSLPDLPDQ LGSPQVGGSL KPALPGSLEY MCLPPGGQAQ LVPLSQVMGQ GQAMDVQCGS
SLETSGSPSV EPKENPPVEL SMEEQEARDN PVTLPISSGG PEGSMMASDY VTPGDPVLTL
PTGPLSTSLG PSLGLPSAQS PRLCLKLPRV PSGSPALGPP GFEDYVELPP SVSQAAKSPP
GHPAPPVASS PTVIPGEPRE EVGPASPHPE GLLVLQQVGD YCFLPGLGPG SLSPHSKPPS
PSLCSETEDL VQDLSVKKFP YQPMPQAPAI QFFKSLKHQD YLSLPPWDNS QSGKVC
Records:
Category Evidence Reference
A Peptide library Velazquez L, Gish GD, van Der Geer P, Taylor L, Shulman J, Pawson T., The shc adaptor protein forms interdependent phosphotyrosine-mediated protein complexes in mast cells stimulated with interleukin 3., [10891441]
End of Record Details