ul_1802----
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PPBD protein
Gene name SHC1
Synonyms SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_003020
SwissProt accession P29353
Substrate protein
Gene name FGFR1
Synonyms CD331 antigen; EC 2.7.10.1; FGFR-1; Fms-like tyrosine kinase 2; bFGF-R; c-fgr
GO annotations GO_component: integral to plasma membrane [PMID 10918587]; membrane; membrane fraction
GO_function:ATP binding; fibroblast growth factor receptor activity [PMID 1846977] [PMID 2159626] [PMID 2167437]; heparin binding; nucleotide binding; protein binding [PMID 9660748]; protein-tyrosine kinase activity [PMID 1846977] [PMID 2159626]; receptor activity; transferase activity
GO_process: cell growth; fibroblast growth factor receptor signaling pathway [PMID 2159626]; MAPKKK cascade [PMID 10748122]; protein amino acid phosphorylation [PMID 1846977] [PMID 2159626]; skeletal development [PMID 7874169]
RefSeq accession NP_075598
SwissProt accession P11362
Sequence:(RefSeq accession:NP_075598; substrate region highlighted if known)
1
61
121
MWSWKCLLFW AVLVTATLCT ARPSPTLPEQ AQPWGAPVEV ESFLVHPGDL LQLRCRLRDD
VQSINWLRDG VQLAESNRTR ITGEEVEVQD SVPADSGLYA CVTSSPSGSD TTYFSVNVSA
CPDLQEAKWC SASFHSITPL PFGLGTRLSD
Records:
Category Evidence Reference
A Inference Dunican DJ, Williams EJ, Howell FV, Doherty P., Selective inhibition of fibroblast growth factor (FGF)-stimulated mitogenesis by a FGF receptor-1-derived phosphopeptide., [11373272]
End of Record Details