ul_1826----
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PPBD protein
Gene name TLN1( Description: talin 1. )
Synonyms ILWEQ; KIAA1027; TLN
GO annotations GO_component: cytoskeleton; cytosol; focal adhesion [PMID 10610730]; intercellular junction [PMID 15494027]; ruffle
GO_function:actin binding; binding; LIM domain binding [PMID 10320340]; protein binding; structural constituent of cytoskeleton [PMID 10610730]; vinculin binding [PMID 15070891]
GO_process: cell motility [PMID 10610730]; cytoskeletal anchoring [PMID 10610730]; intercellular junction assembly [PMID 15494027]
RefSeq accession NP_006280
SwissProt accession Q9Y490
Substrate protein
Gene name ITGB3( Description: integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61). )
Synonyms CD61; CD61 antigen; GP3A; GPIIIa; Platelet membrane glycoprotein IIIa
GO annotations GO_component: integrin complex [PMID 1438206]; membrane
GO_function:identical protein binding [PMID 11606749]; receptor activity
GO_process: blood coagulation [PMID 1438206]; cell adhesion [PMID 2452834] [PMID 10429193]; cell-matrix adhesion; development; integrin-mediated signaling pathway
RefSeq accession NP_000203
SwissProt accession P05106
GO Pathway:
GO:0007155     cell adhesion
Sequence:(RefSeq accession:NP_000203; substrate region highlighted if known)
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MRARPRPRPL WATVLALGAL AGVGVGGPNI CTTRGVSSCQ QCLAVSPMCA WCSDEALPLG
SPRCDLKENL LKDNCAPESI EFPVSEARVL EDRPLSDKGS GDSSQVTQVS PQRIALRLRP
DDSKNFSIQV RQVEDYPVDI YYLMDLSYSM KDDLWSIQNL GTKLATQMRK LTSNLRIGFG
AFVDKPVSPY MYISPPEALE NPCYDMKTTC LPMFGYKHVL TLTDQVTRFN EEVKKQSVSR
NRDAPEGGFD AIMQATVCDE KIGWRNDASH LLVFTTDAKT HIALDGRLAG IVQPNDGQCH
VGSDNHYSAS TTMDYPSLGL MTEKLSQKNI NLIFAVTENV VNLYQNYSEL IPGTTVGVLS
MDSSNVLQLI VDAYGKIRSK VELEVRDLPE ELSLSFNATC LNNEVIPGLK SCMGLKIGDT
VSFSIEAKVR GCPQEKEKSF TIKPVGFKDS LIVQVTFDCD CACQAQAEPN SHRCNNGNGT
FECGVCRCGP GWLGSQCECS EEDYRPSQQD ECSPREGQPV CSQRGECLCG QCVCHSSDFG
KITGKYCECD DFSCVRYKGE MCSGHGQCSC GDCLCDSDWT GYYCNCTTRT DTCMSSNGLL
CSGRGKCECG SCVCIQPGSY GDTCEKCPTC PDACTFKKEC VECKKFDRGA LHDENTCNRY
CRDEIESVKE LKDTGKDAVN CTYKNEDDCV VRFQYYEDSS GKSILYVVEE PECPKGPDIL
VVLLSVMGAI LLIGLAALLI WKLLITIHDR KEFAKFEEER ARAKWDTANN PLYKEATSTF
TNITYRGT
Records:
Category Evidence Reference
A Mutagenesis Calderwood DA, Yan B, de Pereda JM, Alvarez BG, Fujioka Y, Liddington RC, Ginsberg MH., The phosphotyrosine binding-like domain of talin activates integrins., [11932255]
End of Record Details