ul_1841----
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PPBD protein
Gene name ABL1
Synonyms Abelson murine leukemia viral oncogene homolog 1; EC 2.7.10.2; c-ABL; p150
GO annotations GO_component: nucleus [PMID 8242749]
GO_function:ATP binding; DNA binding [PMID 8242749]; nucleotide binding; protein C-terminus binding [PMID 11971963]; protein-tyrosine kinase activity [PMID 10391249]; transferase activity
GO_process: DNA damage response, signal transduction resulting in induction of apoptosis [PMID 10391249]; intracellular signaling cascade; mismatch repair [PMID 10391249]; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8242749]; regulation of transcription, DNA-dependent [PMID 8242749]; S-phase-specific transcription in mitotic cell cycle [PMID 8242749]
RefSeq accession NP_005148
SwissProt accession P00519
Substrate protein
Gene name BCAR1( Description: breast cancer anti-estrogen resistance 1. )
Synonyms CAS; CRK-associated substrate; CRKAS; P130Cas; p130cas
GO annotations GO_component: cytoplasm [PMID 8070403]; focal adhesion; membrane fraction [PMID 8070403]; ruffle [PMID 9472046]
GO_function:protein binding [PMID 9748234] [PMID 10339567] [PMID 10587647] [PMID 11782456] [PMID 14688263] [PMID 16105984]; protein kinase binding [PMID 8070403] [PMID 8649368] [PMID 9020138] [PMID 9472046] [PMID 10026197] [PMID 16245368]; protein phosphatase binding [PMID 9285683]; signal transducer activity [PMID 8070403]
GO_process: actin filament organization [PMID 16105984]; B cell receptor signaling pathway [PMID 9020138]; cell adhesion; cell division [PMID 10675905]; cell migration [PMID 9425168]; cell proliferation [PMID 10639512]; epidermal growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway [PMID 10092204]; insulin receptor signaling pathway; integrin-mediated signaling pathway [PMID 8649368]; nerve growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration [PMID 9472046]; regulation of apoptosis [PMID 11607844]; regulation of cell growth [PMID 11607844]; T cell receptor signaling pathway [PMID 9295052]
RefSeq accession NP_055382
SwissProt accession P56945
Sequence:(RefSeq accession:NP_055382; substrate region highlighted if known)
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MNHLNVLAKA LYDNVAESPD ELSFRKGDIM TVLEQDTQGL DGWWLCSLHG RQGIVPGNRL
KILVGMYDKK PAGPGPGPPA TPAQPQPGLH APAPPASQYT PMLPNTYQPQ PDSVYLVPTP
SKAQQGLYQV PGPSPQFQSP PAKQTSTFSK QTPHHPFPSP ATDLYQVPPG PGGPAQDIYQ
VPPSAGMGHD IYQVPPSMDT RSWEGTKPPA KVVVPTRVGQ GYVYEAAQPE QDEYDIPRHL
LAPGPQDIYD VPPVRGLLPS QYGQEVYDTP PMAVKGPNGR DPLLEVYDVP PSVEKGLPPS
NHHAVYDVPP SVSKDVPDGP LLREETYDVP PAFAKAKPFD PARTPLVLAA PPPDSPPAED
VYDVPPPAPD LYDVPPGLRR PGPGTLYDVP RERVLPPEVA DGGVVDSGVY AVPPPAEREA
PAEGKRLSAS STGSTRSSQS ASSLEVAGPG REPLELEVAV EALARLQQGV SATVAHLLDL
AGSAGATGSW RSPSEPQEPL VQDLQAAVAA VQSAVHELLE FARSAVGNAA HTSDRALHAK
LSRQLQKMED VHQTLVAHGQ ALDAGRGGSG ATLEDLDRLV ACSRAVPEDA KQLASFLHGN
ASLLFRRTKA TAPGPEGGGT LHPNPTDKTS SIQSRPLPSP PKFTSQDSPD GQYENSEGGW
MEDYDYVHLQ GKEEFEKTQK ELLEKGSITR QGKSQLELQQ LKQFERLEQE VSRPIDHDLA
NWTPAQPLAP GRTGGLGPSD RQLLLFYLEQ CEANLTTLTN AVDAFFTAVA TNQPPKIFVA
HSKFVILSAH KLVFIGDTLS RQAKAADVRS QVTHYSNLLC DLLRGIVATT KAAALQYPSP
SAAQDMVERV KELGHSTQQF RRVLGQLAAA
Records:
Category Evidence Reference
A Inference Songyang Z, Carraway KL 3rd, Eck MJ, Harrison SC, Feldman RA, Mohammadi M, Schlessinger J, Hubbard SR, Smith DP, Eng C, et al., Catalytic specificity of protein-tyrosine kinases is critical for selective signalling, [7845468]
End of Record Details