ul_1906----
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PPBD protein
Gene name ABL1
Synonyms Abelson murine leukemia viral oncogene homolog 1; EC 2.7.10.2; c-ABL; p150
GO annotations GO_component: nucleus [PMID 8242749]
GO_function:ATP binding; DNA binding [PMID 8242749]; nucleotide binding; protein C-terminus binding [PMID 11971963]; protein-tyrosine kinase activity [PMID 10391249]; transferase activity
GO_process: DNA damage response, signal transduction resulting in induction of apoptosis [PMID 10391249]; intracellular signaling cascade; mismatch repair [PMID 10391249]; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8242749]; regulation of transcription, DNA-dependent [PMID 8242749]; S-phase-specific transcription in mitotic cell cycle [PMID 8242749]
RefSeq accession NP_005148
SwissProt accession P00519
Substrate protein
Gene name DOK2( Description: docking protein 2, 56kDa. )
Synonyms Downstream of tyrosine kinase 2; p56(dok-2); p56DOK; p56dok-2
GO annotations GO_component:
GO_function:insulin receptor binding; protein binding [PMID 10799545]
GO_process: cell surface receptor linked signal transduction [PMID 10799545]
RefSeq accession NP_003965
SwissProt accession O60496
GO Pathway:
GO:0030036     actin cytoskeleton organization and biogenesis
Sequence:(RefSeq accession:NP_003965; substrate region highlighted if known)
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MGDGAVKQGF LYLQQQQTFG KKWRRFGASL YGGSDCALAR LELQEGPEKP RRCEAARKVI
RLSDCLRVAE AGGEASSPRD TSAFFLETKE RLYLLAAPAA ERGDWVQAIC LLAFPGQRKE
LSGPEGKQSR PCMEENELYS SAVTVGPHKE FAVTMRPTEA SERCHLRGSY TLRAGESALE
LWGGPEPGTQ LYDWPYRFLR RFGRDKVTFS FEAGRRCVSG EGNFEFETRQ GNEIFLALEE
AISAQKNAAP ATPQPQPATI PASLPRPDSP YSRPHDSLPP PSPTTPVPAP RPRGQEGEYA
VPFDAVARSL GKNFRGILAV PPQLLADPLY DSIEETLPPR PDHIYDEPEG VAALSLYDSP
QEPRGEAWRR QATADRDPAG LQHVQPAGQD FSASGWQPGT EYDNVVLKKG PK
Records:
Category Evidence Reference
A Inference Master Z, Tran J, Bishnoi A, Chen SH, Ebos JM, Van Slyke P, Kerbel RS, Dumont DJ., Dok-R binds c-Abl and regulates Abl kinase activity and mediates cytoskeletal reorganization, [12777393]
End of Record Details