ul_1917----
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PPBD protein
Gene name ABL1
Synonyms Abelson murine leukemia viral oncogene homolog 1; EC 2.7.10.2; c-ABL; p150
GO annotations GO_component: nucleus [PMID 8242749]
GO_function:ATP binding; DNA binding [PMID 8242749]; nucleotide binding; protein C-terminus binding [PMID 11971963]; protein-tyrosine kinase activity [PMID 10391249]; transferase activity
GO_process: DNA damage response, signal transduction resulting in induction of apoptosis [PMID 10391249]; intracellular signaling cascade; mismatch repair [PMID 10391249]; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8242749]; regulation of transcription, DNA-dependent [PMID 8242749]; S-phase-specific transcription in mitotic cell cycle [PMID 8242749]
RefSeq accession NP_005148
SwissProt accession P00519
Substrate protein
Gene name ERBB4( Description: v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian). )
Synonyms EC 2.7.10.1; HER4; MGC138404; Tyrosine kinase-type cell surface receptor HER4; p180erbB4
GO annotations GO_component: integral to plasma membrane [PMID 8383326]; membrane
GO_function:ATP binding; epidermal growth factor receptor activity; nucleotide binding; protein binding [PMID 9419975] [PMID 10572067]; protein heterodimerization activity [PMID 10572067]; receptor activity; transferase activity
GO_process: cell proliferation [PMID 8383326]; development [PMID 8383326]; protein amino acid phosphorylation; signal transduction [PMID 10572067]; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_005226
SwissProt accession Q15303
Sequence:(RefSeq accession:NP_005226; substrate region highlighted if known)
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MKPATGLWVW VSLLVAAGTV QPSDSQSVCA GTENKLSSLS DLEQQYRALR KYYENCEVVM
GNLEITSIEH NRDLSFLRSV REVTGYVLVA LNQFRYLPLE NLRIIRGTKL YEDRYALAIF
LNYRKDGNFG LQELGLKNLT EILNGGVYVD QNKFLCYADT IHWQDIVRNP WPSNLTLVST
NGSSGCGRCH KSCTGRCWGP TENHCQTLTR TVCAEQCDGR CYGPYVSDCC HRECAGGCSG
PKDTDCFACM NFNDSGACVT QCPQTFVYNP TTFQLEHNFN AKYTYGAFCV KKCPHNFVVD
SSSCVRACPS SKMEVEENGI KMCKPCTDIC PKACDGIGTG SLMSAQTVDS SNIDKFINCT
KINGNLIFLV TGIHGDPYNA IEAIDPEKLN VFRTVREITG FLNIQSWPPN MTDFSVFSNL
VTIGGRVLYS GLSLLILKQQ GITSLQFQSL KEISAGNIYI TDNSNLCYYH TINWTTLFST
INQRIVIRDN RKAENCTAEG MVCNHLCSSD GCWGPGPDQC LSCRRFSRGR ICIESCNLYD
GEFREFENGS ICVECDPQCE KMEDGLLTCH GPGPDNCTKC SHFKDGPNCV EKCPDGLQGA
NSFIFKYADP DRECHPCHPN CTQGCNGPTS HDCIYYPWTG HSTLPQHART PLIAAGVIGG
LFILVIVGLT FAVYVRRKSI KKKRALRRFL ETELVEPLTP SGTAPNQAQL RILKETELKR
VKVLGSGAFG TVYKGIWVPE GETVKIPVAI KILNETTGPK ANVEFMDEAL IMASMDHPHL
VRLLGVCLSP TIQLVTQLMP HGCLLEYVHE HKDNIGSQLL LNWCVQIAKG MMYLEERRLV
HRDLAARNVL VKSPNHVKIT DFGLARLLEG DEKEYNADGG KMPIKWMALE CIHYRKFTHQ
SDVWSYGVTI WELMTFGGKP YDGIPTREIP DLLEKGERLP QPPICTIDVY MVMVKCWMID
ADSRPKFKEL AAEFSRMARD PQRYLVIQGD DRMKLPSPND SKFFQNLLDE EDLEDMMDAE
EYLVPQAFNI PPPIYTSRAR IDSNRSEIGH SPPPAYTPMS GNQFVYRDGG FAAEQGVSVP
YRAPTSTIPE APVAQGATAE IFDDSCCNGT LRKPVAPHVQ EDSSTQRYSA DPTVFAPERS
PRGELDEEGY MTPMRDKPKQ EYLNPVEENP FVSRRKNGDL QALDNPEYHN ASNGPPKAED
EYVNEPLYLN TFANTLGKAE YLKNNILSMP EKAKKAFDNP DYWNHSLPPR STLQHPDYLQ
EYSTKYFYKQ NGRIRPIVAE NPEYLSEFSL KPGTVLPPPP YRHRNTVV
Records:
Category Evidence Reference
A Peptide affinity isolation Jones RB, Gordus A, Krall JA, MacBeath G., A quantitative protein interaction network for the ErbB receptors using protein microarrays, [16273093]
End of Record Details