ul_1918----
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PPBD protein
Gene name ABL1
Synonyms Abelson murine leukemia viral oncogene homolog 1; EC 2.7.10.2; c-ABL; p150
GO annotations GO_component: nucleus [PMID 8242749]
GO_function:ATP binding; DNA binding [PMID 8242749]; nucleotide binding; protein C-terminus binding [PMID 11971963]; protein-tyrosine kinase activity [PMID 10391249]; transferase activity
GO_process: DNA damage response, signal transduction resulting in induction of apoptosis [PMID 10391249]; intracellular signaling cascade; mismatch repair [PMID 10391249]; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8242749]; regulation of transcription, DNA-dependent [PMID 8242749]; S-phase-specific transcription in mitotic cell cycle [PMID 8242749]
RefSeq accession NP_005148
SwissProt accession P00519
Substrate protein
Gene name MUC1( Description: mucin 1, cell surface associated. )
Synonyms Breast carcinoma-associated; CD227; Carcinoma-associated mucin; EMA; Episialin; H23AG; MAM6; MUC-1; PEM; PEMT; PUM; Peanut-reactive urinary mucin; Polymorphic epithelial mucin; Tumor-associated epithelial membrane antigen; Tumor-associated mucin
GO annotations GO_component: cytoskeleton; extracellular region; integral to membrane; integral to plasma membrane [PMID 1697589]; membrane
GO_function:actin binding; hormone activity
GO_process:
RefSeq accession NP_002447
SwissProt accession P15941
Sequence:(RefSeq accession:NP_002447; substrate region highlighted if known)
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MTPGTQSPFF LLLLLTVLTV VTGSGHASST PGGEKETSAT QRSSVPSSTE KNALSTGVSF
FFLSFHISNL QFNSSLEDPS TDYYQELQRD ISEMFLQIYK QGGFLGLSNI KFRPGSVVVQ
LTLAFREGTI NVHDVETQFN QYKTEAASRY NLTISDVSVS DVPFPFSAQS GAGVPGWGIA
LLVLVCVLVA LAIVYLIALA VCQCRRKNYG QLDIFPARDT YHPMSEYPTY HTHGRYVPPS
STDRSPYEKV SAGNGGSSLS YTNPAVAATS ANL
Records:
Category Evidence Reference
A Mutagenesis Raina D, Ahmad R, Kumar S, Ren J, Yoshida K, Kharbanda S, Kufe D., MUC1 oncoprotein blocks nuclear targeting of c-Abl in the apoptotic response to DNA damage, [16888623]
End of Record Details