ul_1921----
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PPBD protein
Gene name ABL2
Synonyms Abelson murine leukemia viral oncogene homolog 2; Abelson-related gene protein; EC 2.7.10.2; Tyrosine kinase ARG
GO annotations GO_component: cytoplasm; phosphoinositide 3-kinase complex
GO_function:ATP binding; nucleotide binding; phosphoinositide 3-kinase regulator activity; protein-tyrosine kinase activity; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation
RefSeq accession NP_005149
SwissProt accession P42684
Substrate protein
Gene name RIN1( Description: Ras and Rab interactor 1. )
Synonyms Ras inhibitor JC99; Ras interaction/interference protein 1
GO annotations GO_component: cytoskeleton; plasma membrane [PMID 7862125] [PMID 9144171]
GO_function:GTPase activator activity; protein binding [PMID 9144171]
GO_process: endocytosis; intracellular signaling cascade; signal transduction
RefSeq accession NP_004283
SwissProt accession Q13671
GO Pathway:
GO:0005856     cytoskeleton
Sequence:(RefSeq accession:NP_004283; substrate region highlighted if known)
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MESPGESGAG SPGAPSPSSF TTGHLAREKP AQDPLYDVPN ASGGQAGGPQ RPGRVVSLRE
RLLLTRPVWL QLQANAAAAL HMLRTEPPGT FLVRKSNTRQ CQALCMRLPE ASGPSFVSSH
YILESPGGVS LEGSELMFPD LVQLICAYCH TRDILLLPLQ LPRAIHHAAT HKELEAISHL
GIEFWSSSLN IKAQRGPAGG PVLPQLKARS PQELDQGTGA ALCFFNPLFP GDLGPTKREK
FKRSFKVRVS TETSSPLSPP AVPPPPVPVL PGAVPSQTER LPPCQLLRRE SSVGYRVPAG
SGPSLPPMPS LQEVDCGSPS SSEEEGVPGS RGSPATSPHL GRRRPLLRSM SAAFCSLLAP
ERQVGRAAAA LMQDRHTAAG QLVQDLLTQV RAGPEPQELQ GIRQALSRAR AMLSAELGPE
KLLSPKRLEH VLEKSLHCSV LKPLRPILAA RLRRRLAADG SLGRLAEGLR LARAQGPGAF
GSHLSLPSPV ELEQVRQKLL QLLRTYSPSA QVKRLLQACK LLYMALRTQE GEGAGADEFL
PLLSLVLAHC DLPELLLEAE YMSELLEPSL LTGEGGYYLT SLSASLALLS GLGQAHTLPL
SPVQELRRSL SLWEQRRLPA THCFQHLLRV AYQDPSSGCT SKTLAVPPEA SIATLNQLCA
TKFRVTQPNT FGLFLYKEQG YHRLPPGALA HRLPTTGYLV YRRAEWPETQ GAVTEEEGSG
QSEARSRGEE QGCQGDGDAG VKASPRDIRE QSETTAEGGQ GQAQEGPAQP GEPEAEGSRA
AEE
Records:
Category Evidence Reference
A Inference Hu H, Bliss JM, Wang Y, Colicelli J., RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration, [15886098]
End of Record Details