ul_1951----
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PPBD protein
Gene name APS( Description: SH2B adaptor protein 2. )
Synonyms APS
GO annotations GO_component: cytoplasm [PMID 9989826]; plasma membrane [PMID 9989826]
GO_function:JAK pathway signal transduction adaptor activity [PMID 10374881]; SH3/SH2 adaptor activity [PMID 9233773]
GO_process: antimicrobial humoral response (sensu Vertebrata); intracellular signaling cascade [PMID 9233773]
RefSeq accession NP_066189
SwissProt accession
Substrate protein
Gene name INSR( Description: insulin receptor. )
Synonyms CD220; CD220 antigen; EC 2.7.10.1; HHF5; IR
GO annotations GO_component: integral to plasma membrane [PMID 2859121]; plasma membrane [PMID 9092559]
GO_function:ATP binding; epidermal growth factor receptor activity; insulin binding [PMID 8440175]; insulin receptor activity [PMID 8440175]; insulin receptor substrate binding [PMID 7537849] [PMID 7559478]; nucleotide binding; phosphoinositide 3-kinase binding [PMID 7537849] [PMID 8276809]; protein-tyrosine kinase activity; PTB domain binding [PMID 7559478]; receptor activity [PMID 1986371]; receptor signaling protein tyrosine kinase activity [PMID 6849137]; SH2 domain binding [PMID 8276809]; transferase activity; transmembrane receptor protein tyrosine kinase signaling protein activity [PMID 1607076]
GO_process: carbohydrate metabolism [PMID 2859121]; development [PMID 7693131]; generation of precursor metabolites and energy [PMID 2859121]; insulin receptor signaling pathway [PMID 8440175]; protein amino acid autophosphorylation [PMID 7537849]; protein amino acid phosphorylation; protein heterotetramerization [PMID 1898103]; signal transduction [PMID 6849137]
RefSeq accession NP_000199
SwissProt accession P06213
Sequence:(RefSeq accession:NP_000199; substrate region highlighted if known)
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MGTGGRRGAA AAPLLVAVAA LLLGAAGHLY PGEVCPGMDI RNNLTRLHEL ENCSVIEGHL
QILLMFKTRP EDFRDLSFPK LIMITDYLLL FRVYGLESLK DLFPNLTVIR GSRLFFNYAL
VIFEMVHLKE LGLYNLMNIT RGSVRIEKNN ELCYLATIDW SRILDSVEDN HIVLNKDDNE
ECGDICPGTA KGKTNCPATV INGQFVERCW THSHCQKVCP TICKSHGCTA EGLCCHSECL
GNCSQPDDPT KCVACRNFYL DGRCVETCPP PYYHFQDWRC VNFSFCQDLH HKCKNSRRQG
CHQYVIHNNK CIPECPSGYT MNSSNLLCTP CLGPCPKVCH LLEGEKTIDS VTSAQELRGC
TVINGSLIIN IRGGNNLAAE LEANLGLIEE ISGYLKIRRS YALVSLSFFR KLRLIRGETL
EIGNYSFYAL DNQNLRQLWD WSKHNLTTTQ GKLFFHYNPK LCLSEIHKME EVSGTKGRQE
RNDIALKTNG DKASCENELL KFSYIRTSFD KILLRWEPYW PPDFRDLLGF MLFYKEAPYQ
NVTEFDGQDA CGSNSWTVVD IDPPLRSNDP KSQNHPGWLM RGLKPWTQYA IFVKTLVTFS
DERRTYGAKS DIIYVQTDAT NPSVPLDPIS VSNSSSQIIL KWKPPSDPNG NITHYLVFWE
RQAEDSELFE LDYCLKGLKL PSRTWSPPFE SEDSQKHNQS EYEDSAGECC SCPKTDSQIL
KELEESSFRK TFEDYLHNVV FVPRKTSSGT GAEDPRPSRK RRSLGDVGNV TVAVPTVAAF
PNTSSTSVPT SPEEHRPFEK VVNKESLVIS GLRHFTGYRI ELQACNQDTP EERCSVAAYV
SARTMPEAKA DDIVGPVTHE IFENNVVHLM WQEPKEPNGL IVLYEVSYRR YGDEELHLCV
SRKHFALERG CRLRGLSPGN YSVRIRATSL AGNGSWTEPT YFYVTDYLDV PSNIAKIIIG
PLIFVFLFSV VIGSIYLFLR KRQPDGPLGP LYASSNPEYL SASDVFPCSV YVPDEWEVSR
EKITLLRELG QGSFGMVYEG NARDIIKGEA ETRVAVKTVN ESASLRERIE FLNEASVMKG
FTCHHVVRLL GVVSKGQPTL VVMELMAHGD LKSYLRSLRP EAENNPGRPP PTLQEMIQMA
AEIADGMAYL NAKKFVHRDL AARNCMVAHD FTVKIGDFGM TRDIYETDYY RKGGKGLLPV
RWMAPESLKD GVFTTSSDMW SFGVVLWEIT SLAEQPYQGL SNEQVLKFVM DGGYLDQPDN
CPERVTDLMR MCWQFNPKMR PTFLEIVNLL KDDLHPSFPE VSFFHSEENK APESEELEME
FEDMENVPLD RSSHCQREEA GGRDGGSSLG FKRSYEEHIP YTHMNGGKKN GRILTLPRSN
PS
Records:
Category Evidence Reference
A Mutagenesis Ahmed Z, Smith BJ, Kotani K, Wilden P, Pillay TS., APS, an adapter protein with a PH and SH2 domain, is a substrate for the insulin receptor kinase, [10417330]
A Structure Hu J, Liu J, Ghirlando R, Saltiel AR, Hubbard SR., Structural basis for recruitment of the adaptor protein APS to the activated insulin receptor, [14690593]
End of Record Details