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PPBD protein
Gene name CBL( Description: Cas-Br-M (murine) ecotropic retroviral transforming sequence. )
Synonyms C-CBL; CBL2; Casitas B-lineage lymphoma proto-oncogene; EC 6.3.2.-; Proto-oncogene c-CBL; RING finger protein 55; RNF55; Signal transduction protein CBL
GO annotations GO_component: nucleus; plasma membrane [PMID 15465819]
GO_function:calcium ion binding; ligase activity; protein binding [PMID 11891219]; signal transducer activity; transcription factor activity [PMID 2030914]; ubiquitin-protein ligase activity [PMID 15465819]; zinc ion binding
GO_process: cell surface receptor linked signal transduction [PMID 15465819]; epidermal growth factor receptor signaling pathway [PMID 15465819]; intracellular signaling cascade; positive regulation of receptor mediated endocytosis [PMID 15465819]; protein ubiquitination [PMID 15465819]
RefSeq accession NP_005179
SwissProt accession P22681
Substrate protein
Gene name Blnk( Description: B-cell linker. )
Synonyms BASH; Bca; Ly-57; Ly57; Lyw-57; SLP-65
GO annotations GO_component: plasma membrane
GO_function:protein binding
GO_process: B cell activation; defense response
RefSeq accession NP_032554
SwissProt accession
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_032554; substrate region highlighted if known)
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MDKLNKITVP ASQKLRQLQK MVHDIKNNEG GIMDKIKKLK VKGPPSVPRR DYALDSPADE
EEQWSDDFDS DYENPDEHSD SEMYVMPAEE TGDDSYEPPP AEQQTRVVHP ALPFTRGEYV
DNRSSQRHSP PFSKTLPSKP SWPSAKARLA STLPAPNSLQ KPQVPPKPKD LLEDEADYVV
PVEDNDENYI HPRESSPPPA EKAPMVNRST KPNSSSKHMS PPGTVAGRNS GVWDSKSSLP
AAPSPLPRAG KKPATPLKTT PVPPLPNASN VCEEKPVPAE RHRGSSHRQD TVQSPVFPPT
QKPVHQKPVP LPRFPEAGSP AADGPFHSFP FNSTFADQEA ELLGKPWYAG ACDRKSAEEA
LHRSNKDGSF LIRKSSGHDS KQPYTLVAFF NKRVYNIPVR FIEATKQYAL GKKKNGEEYF
GSVVEIVNSH QHNPLVLIDS QNNTKDSTRL KYAVKVS
Records:
Category Evidence Reference
A Inference Yasuda T, Maeda A, Kurosaki M, Tezuka T, Hironaka K, Yamamoto T, Kurosaki T., Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-gamma2 activation by regulating B cell linker protein-PLC-gamma2 binding, [10684856]
End of Record Details