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PPBD protein
Gene name CBL( Description: Cas-Br-M (murine) ecotropic retroviral transforming sequence. )
Synonyms C-CBL; CBL2; Casitas B-lineage lymphoma proto-oncogene; EC 6.3.2.-; Proto-oncogene c-CBL; RING finger protein 55; RNF55; Signal transduction protein CBL
GO annotations GO_component: nucleus; plasma membrane [PMID 15465819]
GO_function:calcium ion binding; ligase activity; protein binding [PMID 11891219]; signal transducer activity; transcription factor activity [PMID 2030914]; ubiquitin-protein ligase activity [PMID 15465819]; zinc ion binding
GO_process: cell surface receptor linked signal transduction [PMID 15465819]; epidermal growth factor receptor signaling pathway [PMID 15465819]; intracellular signaling cascade; positive regulation of receptor mediated endocytosis [PMID 15465819]; protein ubiquitination [PMID 15465819]
RefSeq accession NP_005179
SwissProt accession P22681
Substrate protein
Gene name SPRY2( Description: sprouty homolog 2 (Drosophila). )
Synonyms MGC23039; hSPRY2
GO annotations GO_component: membrane; microtubule
GO_function:
GO_process: cell-cell signaling [PMID 9458049]; development; organ morphogenesis [PMID 9458049]; regulation of signal transduction
RefSeq accession NP_005833
SwissProt accession O43597
GO Pathway:
GO:0009966     regulation of signal transduction
Sequence:(RefSeq accession:NP_005833; substrate region highlighted if known)
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MEARAQSGNG SQPLLQTPRD GGRQRGEPDP RDALTQQVHV LSLDQIRAIR NTNEYTEGPT
VVPRPGLKPA PRPSTQHKHE RLHGLPEHRQ PPRLQHSQVH SSARAPLSRS ISTVSSGSRS
STRTSTSSSS SEQRLLGSSF SSGPVADGII RVQPKSELKP GELKPLSKED LGLHAYRCED
CGKCKCKECT YPRPLPSDWI CDKQCLCSAQ NVIDYGTCVC CVKGLFYHCS NDDEDNCADN
PCSCSQSHCC TRWSAMGVMS LFLPCLWCYL PAKGCLKLCQ GCYDRVNRPG CRCKNSNTVC
CKVPTVPPRN FEKPT
Records:
Category Evidence Reference
A Mutagenesis Fong CW, Leong HF, Wong ES, Lim J, Yusoff P, Guy GR., Tyrosine phosphorylation of Sprouty2 enhances its interaction with c-Cbl and is crucial for its function, [12815057]
End of Record Details