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PPBD protein
Gene name CBL( Description: Cas-Br-M (murine) ecotropic retroviral transforming sequence. )
Synonyms C-CBL; CBL2; Casitas B-lineage lymphoma proto-oncogene; EC 6.3.2.-; Proto-oncogene c-CBL; RING finger protein 55; RNF55; Signal transduction protein CBL
GO annotations GO_component: nucleus; plasma membrane [PMID 15465819]
GO_function:calcium ion binding; ligase activity; protein binding [PMID 11891219]; signal transducer activity; transcription factor activity [PMID 2030914]; ubiquitin-protein ligase activity [PMID 15465819]; zinc ion binding
GO_process: cell surface receptor linked signal transduction [PMID 15465819]; epidermal growth factor receptor signaling pathway [PMID 15465819]; intracellular signaling cascade; positive regulation of receptor mediated endocytosis [PMID 15465819]; protein ubiquitination [PMID 15465819]
RefSeq accession NP_005179
SwissProt accession P22681
Substrate protein
Gene name SPRED2( Description: sprouty-related, EVH1 domain containing 2. )
Synonyms FLJ21897; FLJ31917; MGC163164; Spred-2
GO annotations GO_component: membrane
GO_function:protein binding; stem cell factor receptor binding
GO_process: development; inactivation of MAPK activity; regulation of signal transduction
RefSeq accession NP_861449
SwissProt accession Q7Z698
GO Pathway:
GO:0016567     protein ubiquitination
Sequence:(RefSeq accession:NP_861449; substrate region highlighted if known)
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MTEETHPDDD SYIVRVKAVV MTRDDSSGGW FPQEGGGISR VGVCKVMHPE GNGRSGFLIH
GERQKDKLVV LECYVRKDLV YTKANPTFHH WKVDNRKFGL TFQSPADARA FDRGVRKAIE
DLIEGSTTSS STIHNEAELG DDDVFTTATD SSSNSSQKRE QPTRTISSPT SCEHRRIYTL
GHLHDSYPTD HYHLDQPMPR PCRQVSFPDD DEEIVRINPR EKIWMTGYED YRHAPVRGKY
PDPSEDADSS YVRFAKGEVP KHDYNYPYVD SSDFGLGEDP KGRGGSVIKT QPSRGKSRRR
KEDGERSRCV YCRDMFNHEE NRRGHCQDAP DSVRTCIRRV SCMWCADSML YHCMSDPEGD
YTDPCSCDTS DEKFCLRWMA LIALSFLAPC MCCYLPLRAC YHCGVMCRCC GGKHKAAA
Records:
Category Evidence Reference
A Mutagenesis Lock P, I ST, Straffon AF, Schieb H, Hovens CM, Stylli SS., Spred-2 steady-state levels are regulated by phosphorylation and Cbl-mediated ubiquitination, [17094949]
End of Record Details