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PPBD protein
Gene name CBLB( Description: Cas-Br-M (murine) ecotropic retroviral transforming sequence b. )
Synonyms Casitas B-lineage lymphoma proto-oncogene b; DKFZp686J10223; DKFZp779A0729; DKFZp779F1443; EC 6.3.2.-; FLJ36865; FLJ41152; Nbla00127; RING finger protein 56; RNF56; SH3-binding protein CBL-B; Signal transduction protein CBL-B
GO annotations GO_component: nucleus
GO_function:calcium ion binding; ligase activity; protein binding [PMID 7784085]; signal transducer activity; zinc ion binding [PMID 7784085]
GO_process: cell surface receptor linked signal transduction; immune response; intracellular signaling cascade; NLS-bearing substrate import into nucleus [PMID 7784085]; ubiquitin cycle
RefSeq accession NP_733762
SwissProt accession Q13191
Substrate protein
Gene name SYK( Description: spleen tyrosine kinase. )
Synonyms EC 2.7.10.2; Spleen tyrosine kinase
GO annotations GO_component: cytoplasm; T cell receptor complex [PMID 8176201]
GO_function:ATP binding; integrin binding [PMID 12885943]; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding [PMID 8627166] [PMID 9280292] [PMID 12885943]; transferase activity
GO_process: cell proliferation [PMID 10963601]; integrin-mediated signaling pathway [PMID 12885943]; intracellular signaling cascade; leukocyte adhesion [PMID 12885943]; neutrophil chemotaxis [PMID 12885943]; organ morphogenesis [PMID 7477352]; protein amino acid phosphorylation [PMID 8163536]; protein complex assembly [PMID 8163536]
RefSeq accession NP_003168
SwissProt accession P43405
GO Pathway:
GO:0007166     cell surface receptor linked signal transduction
Sequence:(RefSeq accession:NP_003168; substrate region highlighted if known)
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MASSGMADSA NHLPFFFGNI TREEAEDYLV QGGMSDGLYL LRQSRNYLGG FALSVAHGRK
AHHYTIEREL NGTYAIAGGR THASPADLCH YHSQESDGLV CLLKKPFNRP QGVQPKTGPF
EDLKENLIRE YVKQTWNLQG QALEQAIISQ KPQLEKLIAT TAHEKMPWFH GKISREESEQ
IVLIGSKTNG KFLIRARDNN GSYALCLLHE GKVLHYRIDK DKTGKLSIPE GKKFDTLWQL
VEHYSYKADG LLRVLTVPCQ KIGTQGNVNF GGRPQLPGSH PATWSAGGII SRIKSYSFPK
PGHRKSSPAQ GNRQESTVSF NPYEPELAPW AADKGPQREA LPMDTEVYES PYADPEEIRP
KEVYLDRKLL TLEDKELGSG NFGTVKKGYY QMKKVVKTVA VKILKNEAND PALKDELLAE
ANVMQQLDNP YIVRMIGICE AESWMLVMEM AELGPLNKYL QQNRHVKDKN IIELVHQVSM
GMKYLEESNF VHRDLAARNV LLVTQHYAKI SDFGLSKALR ADENYYKAQT HGKWPVKWYA
PECINYYKFS SKSDVWSFGV LMWEAFSYGQ KPYRGMKGSE VTAMLEKGER MGCPAGCPRE
MYDLMNLCWT YDVENRPGFA AVELRLRNYY YDVVN
Records:
Category Evidence Reference
A Mutagenesis Elly C, Witte S, Zhang Z, Rosnet O, Lipkowitz S, Altman A, Liu YC., Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation, [10022120]
End of Record Details