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PPBD protein
Gene name CHN1( Description: chimerin (chimaerin) 1. )
Synonyms A-chimaerin; ARHGAP2; Alpha-chimerin; CHN; N-chimerin; NC; RHOGAP2; Rho GTPase-activating protein 2
GO annotations GO_component: intracellular
GO_function:diacylglycerol binding; GTPase activator activity; metal ion binding; SH3/SH2 adaptor activity [PMID 8336731]; zinc ion binding
GO_process: intracellular signaling cascade
RefSeq accession NP_001813
SwissProt accession P15882
Substrate protein
Gene name EGFR
Synonyms EC 2.7.10.1; Receptor tyrosine-protein kinase ErbB-1
GO annotations GO_component: AP-2 adaptor complex [PMID 14702346]; cytoplasm [PMID 12435727]; endosome [PMID 14702346]; extracellular space [PMID 9103388]; integral to membrane; nucleus [PMID 12828935]; plasma membrane [PMID 15465819]
GO_function:actin filament binding [PMID 14702346]; ATP binding; double-stranded DNA binding [PMID 6325948]; epidermal growth factor receptor activity [PMID 2790960] [PMID 6325948] [PMID 12435727]; identical protein binding [PMID 16777603]; MAP/ERK kinase kinase activity [PMID 15542601]; nitric-oxide synthase regulator activity [PMID 12828935]; nucleotide binding; protein heterodimerization activity [PMID 10572067]; transferase activity; transmembrane receptor activity [PMID 7736574]
GO_process: calcium-dependent phospholipase A2 activation [PMID 12435727]; cell cycle; cell proliferation [PMID 10861448]; cell surface receptor linked signal transduction [PMID 7736574]; cell-cell adhesion [PMID 12435727]; epidermal growth factor receptor signaling pathway [PMID 12435727]; negative regulation of progression through cell cycle; ossification [PMID 12925580]; phospholipase C activation [PMID 12435727]; positive regulation of cell migration [PMID 12435727]; positive regulation of epithelial cell proliferation [PMID 10572067]; positive regulation of MAPK activity [PMID 10572067]; positive regulation of nitric oxide biosynthesis [PMID 12828935]; positive regulation of phosphorylation [PMID 15082764]; protein amino acid phosphorylation; protein insertion into membrane [PMID 12435727]; regulation of nitric-oxide synthase activity [PMID 12828935]; regulation of peptidyl-tyrosine phosphorylation [PMID 12435727]; response to stress [PMID 12828935]
RefSeq accession NP_005219
SwissProt accession P00533
Sequence:(RefSeq accession:NP_005219; substrate region highlighted if known)
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61
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721
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841
901
961
1021
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1201
MRPSGTAGAA LLALLAALCP ASRALEEKKV CQGTSNKLTQ LGTFEDHFLS LQRMFNNCEV
VLGNLEITYV QRNYDLSFLK TIQEVAGYVL IALNTVERIP LENLQIIRGN MYYENSYALA
VLSNYDANKT GLKELPMRNL QEILHGAVRF SNNPALCNVE SIQWRDIVSS DFLSNMSMDF
QNHLGSCQKC DPSCPNGSCW GAGEENCQKL TKIICAQQCS GRCRGKSPSD CCHNQCAAGC
TGPRESDCLV CRKFRDEATC KDTCPPLMLY NPTTYQMDVN PEGKYSFGAT CVKKCPRNYV
VTDHGSCVRA CGADSYEMEE DGVRKCKKCE GPCRKVCNGI GIGEFKDSLS INATNIKHFK
NCTSISGDLH ILPVAFRGDS FTHTPPLDPQ ELDILKTVKE ITGFLLIQAW PENRTDLHAF
ENLEIIRGRT KQHGQFSLAV VSLNITSLGL RSLKEISDGD VIISGNKNLC YANTINWKKL
FGTSGQKTKI ISNRGENSCK ATGQVCHALC SPEGCWGPEP RDCVSCRNVS RGRECVDKCN
LLEGEPREFV ENSECIQCHP ECLPQAMNIT CTGRGPDNCI QCAHYIDGPH CVKTCPAGVM
GENNTLVWKY ADAGHVCHLC HPNCTYGCTG PGLEGCPTNG PKIPSIATGM VGALLLLLVV
ALGIGLFMRR RHIVRKRTLR RLLQERELVE PLTPSGEAPN QALLRILKET EFKKIKVLGS
GAFGTVYKGL WIPEGEKVKI PVAIKELREA TSPKANKEIL DEAYVMASVD NPHVCRLLGI
CLTSTVQLIT QLMPFGCLLD YVREHKDNIG SQYLLNWCVQ IAKGMNYLED RRLVHRDLAA
RNVLVKTPQH VKITDFGLAK LLGAEEKEYH AEGGKVPIKW MALESILHRI YTHQSDVWSY
GVTVWELMTF GSKPYDGIPA SEISSILEKG ERLPQPPICT IDVYMIMVKC WMIDADSRPK
FRELIIEFSK MARDPQRYLV IQGDERMHLP SPTDSNFYRA LMDEEDMDDV VDADEYLIPQ
QGFFSSPSTS RTPLLSSLSA TSNNSTVACI DRNGLQSCPI KEDSFLQRYS SDPTGALTED
SIDDTFLPVP EYINQSVPKR PAGSVQNPVY HNQPLNPAPS RDPHYQDPHS TAVGNPEYLN
TVQPTCVNST FDSPAHWAQK GSHQISLDNP DYQQDFFPKE AKPNGIFKGS TAENAEYLRV
APQSSEFIGA
Records:
Category Evidence Reference
A Peptide affinity isolation Jones RB, Gordus A, Krall JA, MacBeath G., A quantitative protein interaction network for the ErbB receptors using protein microarrays, [16273093]
End of Record Details