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PPBD protein
Gene name CHN2( Description: chimerin (chimaerin) 2. )
Synonyms ARHGAP3; BCH; Beta-chimerin; MGC138360; RHOGAP3; Rho GTPase-activating protein 3
GO annotations GO_component: intracellular
GO_function:diacylglycerol binding; GTPase activator activity [PMID 7614486]; metal ion binding; SH3/SH2 adaptor activity [PMID 8175705]; zinc ion binding
GO_process: intracellular signaling cascade
RefSeq accession NP_004058
SwissProt accession P52757
Substrate protein
Gene name ERBB2
Synonyms C-erbB-2; CD340 antigen; EC 2.7.10.1; MLN 19; NEU proto-oncogene; Tyrosine kinase-type cell surface receptor HER2; p185erbB2
GO annotations GO_component: extracellular region [PMID 10485918]; integral to membrane [PMID 15609325]; membrane; plasma membrane [PMID 12000754]
GO_function:ATP binding; electron carrier activity; epidermal growth factor receptor activity [PMID 15504738]; ErbB-3 class receptor binding [PMID 9590694]; iron ion binding; non-membrane spanning protein tyrosine kinase activity [PMID 10485918]; nucleotide binding; protein heterodimerization activity [PMID 10572067] [PMID 15504738]; protein-tyrosine kinase activity; receptor activity; receptor signaling protein tyrosine kinase activity [PMID 10851066]; transferase activity
GO_process: cell proliferation [PMID 10851066]; electron transport; heart development [PMID 15504738]; mammary gland development [PMID 15504738]; nervous system development [PMID 15504738]; phosphoinositide-mediated signaling [PMID 15504738]; positive regulation of epithelial cell proliferation [PMID 10572067]; positive regulation of MAPK activity [PMID 10572067]; protein amino acid phosphorylation [PMID 10851066]; regulation of angiogenesis [PMID 15609325]; transmembrane receptor protein tyrosine kinase signaling pathway [PMID 10485918] [PMID 15609325]
RefSeq accession NP_004439
SwissProt accession P04626
Sequence:(RefSeq accession:NP_004439; substrate region highlighted if known)
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MELAALCRWG LLLALLPPGA ASTQVCTGTD MKLRLPASPE THLDMLRHLY QGCQVVQGNL
ELTYLPTNAS LSFLQDIQEV QGYVLIAHNQ VRQVPLQRLR IVRGTQLFED NYALAVLDNG
DPLNNTTPVT GASPGGLREL QLRSLTEILK GGVLIQRNPQ LCYQDTILWK DIFHKNNQLA
LTLIDTNRSR ACHPCSPMCK GSRCWGESSE DCQSLTRTVC AGGCARCKGP LPTDCCHEQC
AAGCTGPKHS DCLACLHFNH SGICELHCPA LVTYNTDTFE SMPNPEGRYT FGASCVTACP
YNYLSTDVGS CTLVCPLHNQ EVTAEDGTQR CEKCSKPCAR VCYGLGMEHL REVRAVTSAN
IQEFAGCKKI FGSLAFLPES FDGDPASNTA PLQPEQLQVF ETLEEITGYL YISAWPDSLP
DLSVFQNLQV IRGRILHNGA YSLTLQGLGI SWLGLRSLRE LGSGLALIHH NTHLCFVHTV
PWDQLFRNPH QALLHTANRP EDECVGEGLA CHQLCARGHC WGPGPTQCVN CSQFLRGQEC
VEECRVLQGL PREYVNARHC LPCHPECQPQ NGSVTCFGPE ADQCVACAHY KDPPFCVARC
PSGVKPDLSY MPIWKFPDEE GACQPCPINC THSCVDLDDK GCPAEQRASP LTSIISAVVG
ILLVVVLGVV FGILIKRRQQ KIRKYTMRRL LQETELVEPL TPSGAMPNQA QMRILKETEL
RKVKVLGSGA FGTVYKGIWI PDGENVKIPV AIKVLRENTS PKANKEILDE AYVMAGVGSP
YVSRLLGICL TSTVQLVTQL MPYGCLLDHV RENRGRLGSQ DLLNWCMQIA KGMSYLEDVR
LVHRDLAARN VLVKSPNHVK ITDFGLARLL DIDETEYHAD GGKVPIKWMA LESILRRRFT
HQSDVWSYGV TVWELMTFGA KPYDGIPARE IPDLLEKGER LPQPPICTID VYMIMVKCWM
IDSECRPRFR ELVSEFSRMA RDPQRFVVIQ NEDLGPASPL DSTFYRSLLE DDDMGDLVDA
EEYLVPQQGF FCPDPAPGAG GMVHHRHRSS STRSGGGDLT LGLEPSEEEA PRSPLAPSEG
AGSDVFDGDL GMGAAKGLQS LPTHDPSPLQ RYSEDPTVPL PSETDGYVAP LTCSPQPEYV
NQPDVRPQPP SPREGPLPAA RPAGATLERP KTLSPGKNGV VKDVFAFGGA VENPEYLTPQ
GGAAPQPHPP PAFSPAFDNL YYWDQDPPER GAPPSTFKGT PTAENPEYLG LDVPV
Records:
Category Evidence Reference
A Peptide affinity isolation Jones RB, Gordus A, Krall JA, MacBeath G., A quantitative protein interaction network for the ErbB receptors using protein microarrays, [16273093]
End of Record Details