ul_2029----
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PPBD protein
Gene name CISH( Description: cytokine inducible SH2-containing protein. )
Synonyms CIS; CIS-1; G18; Protein G18; SOCS; Suppressor of cytokine signaling
GO annotations GO_component:
GO_function:
GO_process: intracellular signaling cascade [PMID 10902923]; negative regulation of signal transduction; regulation of cell growth [PMID 9465889]
RefSeq accession NP_659508
SwissProt accession Q9NSE2
Substrate protein
Gene name EPOR( Description: erythropoietin receptor. )
Synonyms MGC138358
GO annotations GO_component: integral to plasma membrane [PMID 1848667]; intracellular; membrane
GO_function:erythropoietin receptor activity [PMID 8506290]; guanyl-nucleotide exchange factor activity; protein binding [PMID 11781573] [PMID 15644415]
GO_process: signal transduction [PMID 1668606]; small GTPase mediated signal transduction
RefSeq accession NP_000112
SwissProt accession P19235
GO Pathway:
GO:0001558     regulation of cell growth
Sequence:(RefSeq accession:NP_000112; substrate region highlighted if known)
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MDHLGASLWP QVGSLCLLLA GAAWAPPPNL PDPKFESKAA LLAARGPEEL LCFTERLEDL
VCFWEEAASA GVGPGNYSFS YQLEDEPWKL CRLHQAPTAR GAVRFWCSLP TADTSSFVPL
ELRVTAASGA PRYHRVIHIN EVVLLDAPVG LVARLADESG HVVLRWLPPP ETPMTSHIRY
EVDVSAGNGA GSVQRVEILE GRTECVLSNL RGRTRYTFAV RARMAEPSFG GFWSAWSEPV
SLLTPSDLDP LILTLSLILV VILVLLTVLA LLSHRRALKQ KIWPGIPSPE SEFEGLFTTH
KGNFQLWLYQ NDGCLWWSPC TPFTEDPPAS LEVLSERCWG TMQAVEPGTD DEGPLLEPVG
SEHAQDTYLV LDKWLLPRNP PSEDLPGPGG SVDIVAMDEG SEASSCSSAL ASKPSPEGAS
AASFEYTILD PSSQLLRPWT LCPELPPTPP HLKYLYLVVS DSGISTDYSS GDSQGAQGGL
SDGPYSNPYE NSLIPAAEPL PPSYVACS
Records:
Category Evidence Reference
A Mutagenesis Verdier F, Chretien S, Muller O, Varlet P, Yoshimura A, Gisselbrecht S, Lacombe C, Mayeux P., Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein, [9774439]
A Mutagenesis Montoye T, Lemmens I, Catteeuw D, Eyckerman S, Tavernier J., A systematic scan of interactions with tyrosine motifs in the erythropoietin receptor using a mammalian 2-hybrid approach, [15644415]
End of Record Details