ul_2030----
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PPBD protein
Gene name CISH( Description: cytokine inducible SH2-containing protein. )
Synonyms CIS; CIS-1; G18; Protein G18; SOCS; Suppressor of cytokine signaling
GO annotations GO_component:
GO_function:
GO_process: intracellular signaling cascade [PMID 10902923]; negative regulation of signal transduction; regulation of cell growth [PMID 9465889]
RefSeq accession NP_659508
SwissProt accession Q9NSE2
Substrate protein
Gene name Ghr( Description: growth hormone receptor. )
Synonyms GHR/BP; MGC124963
GO annotations GO_component: cytoplasm; extrinsic to membrane; integral to membrane; integral to plasma membrane; nucleus
GO_function:growth hormone receptor activity; protein binding; receptor activity
GO_process: endocytosis; growth; positive regulation of cell differentiation; skeletal development
RefSeq accession NP_058790
SwissProt accession
GO Pathway:
GO:0009968     negative regulation of signal transduction
Sequence:(RefSeq accession:NP_058790; substrate region highlighted if known)
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MDLWRVFLTL ALAVSSDMFP GSGATPATLG KASPVLQRIN PSLRESSSGK PRFTKCRSPE
LETFSCYWTE GDDHNLKVPG SIQLYYARRI AHEWTPEWKE CPDYVSAGAN SCYFNSSYTS
IWIPYCIKLT TNGDLLDEKC FTVDEIVQPD PPIGLNWTLL NISLPGIRGD IQVSWQPPPS
ADVLKGWIIL EYEIQYKEVN ETKWKTMSPI WSTSVPLYSL RLDKEHEVRV RSRQRSFEKY
SEFSEVLRVT FPQMDTLAAC EEDFRFPWFL IIIFGIFGVA VMLFVVIFSK QQRIKMLILP
PVPVPKIKGI DPDLLKEGKL EEVNTILGIH DNYKPDFYND DSWVEFIELD IDDADEKTEE
SDTDRLLSDD QEKSAGILGA KDDDSGRTSC YDPDILDTDF HTSDMCDGTS EFAQPQKLKA
EADLLCLDQK NLKNSPYDAS LGSLHPSITL TMEDKPQPLL GSETESTHQL PSTPMSSPVS
LANIDFYAQV SDITPAGGVV LSPGQKIKAG LAQGNTQLEV AAPCQENYSM NSAYFCESDA
KKCIAAAPHM EATTCVKPSF NQEDIYITTE SLTTTARMSE TADTAPDAEP VPDYTTVHTV
KSPRGLILNA TALPLPDKKK FLSSCGYVST DQLNKIMQ
Records:
Category Evidence Reference
A Inference Ram PA, Waxman DJ., SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms, [10585430]
End of Record Details