ul_2054----
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PPBD protein
Gene name CISH( Description: cytokine inducible SH2-containing protein. )
Synonyms CIS; CIS-1; G18; Protein G18; SOCS; Suppressor of cytokine signaling
GO annotations GO_component:
GO_function:
GO_process: intracellular signaling cascade [PMID 10902923]; negative regulation of signal transduction; regulation of cell growth [PMID 9465889]
RefSeq accession NP_659508
SwissProt accession Q9NSE2
Substrate protein
Gene name GHR( Description: growth hormone receptor. )
Synonyms GH receptor; GHBP; Somatotropin receptor
GO annotations GO_component: integral to plasma membrane [PMID 2825030]; membrane
GO_function:growth hormone receptor activity [PMID 9140387]; protein binding [PMID 10866662]; receptor activity
GO_process: endocytosis; growth [PMID 9140387]; skeletal development [PMID 9140387]
RefSeq accession NP_000154
SwissProt accession P10912
Sequence:(RefSeq accession:NP_000154; substrate region highlighted if known)
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MDLWQLLLTL ALAGSSDAFS GSEATAAILS RAPWSLQSVN PGLKTNSSKE PKFTKCRSPE
RETFSCHWTD EVHHGTKNLG PIQLFYTRRN TQEWTQEWKE CPDYVSAGEN SCYFNSSFTS
IWIPYCIKLT SNGGTVDEKC FSVDEIVQPD PPIALNWTLL NVSLTGIHAD IQVRWEAPRN
ADIQKGWMVL EYELQYKEVN ETKWKMMDPI LTTSVPVYSL KVDKEYEVRV RSKQRNSGNY
GEFSEVLYVT LPQMSQFTCE EDFYFPWLLI IIFGIFGLTV MLFVFLFSKQ QRIKMLILPP
VPVPKIKGID PDLLKEGKLE EVNTILAIHD SYKPEFHSDD SWVEFIELDI DEPDEKTEES
DTDRLLSSDH EKSHSNLGVK DGDSGRTSCC EPDILETDFN ANDIHEGTSE VAQPQRLKGE
ADLLCLDQKN QNNSPYHDAC PATQQPSVIQ AEKNKPQPLP TEGAESTHQA AHIQLSNPSS
LSNIDFYAQV SDITPAGSVV LSPGQKNKAG MSQCDMHPEM VSLCQENFLM DNAYFCEADA
KKCIPVAPHI KVESHIQPSL NQEDIYITTE SLTTAAGRPG TGEHVPGSEM PVPDYTSIHI
VQSPQGLILN ATALPLPDKE FLSSCGYVST DQLNKIMP
Records:
Category Evidence Reference
A Structure Bullock AN, Debreczeni JE, Edwards AM, Sundstrom M, Knapp S., Crystal structure of the SOCS2-elongin C-elongin B complex defines a prototypical SOCS box ubiquitin ligase, [16675548]
End of Record Details