ul_206----
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PPBD protein
Gene name YWHAB( Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide. )
Synonyms GW128; HS1; KCIP-1; Protein 1054; Protein kinase C inhibitor protein 1
GO annotations GO_component: cytoplasm [PMID 12963375]; perinuclear region [PMID 12963375]
GO_function:monooxygenase activity; protein domain specific binding
GO_process:
RefSeq accession NP_003395
SwissProt accession P31946
Substrate protein
Gene name Rps6ka1( Description: ribosomal protein S6 kinase polypeptide 1. )
Synonyms 90 kDa ribosomal protein S6 kinase 1; EC 2.7.11.1; MAP kinase-activated protein kinase 1a; MAPKAPK1A; RSK-1; Ribosomal S6 kinase 1; S6K-alpha 1; p90-RSK 1; p90S6K; pp90RSK1
GO annotations GO_component: spindle
GO_function:nucleotide binding; protein serine/threonine kinase activity; protein-tyrosine kinase activity; ribosomal protein S6 kinase activity; transcription factor binding; transferase activity
GO_process: positive regulation of transcription; protein amino acid phosphorylation; signal transduction
RefSeq accession NP_112369
SwissProt accession Q63531
GO Pathway:
GO:0004711     ribosomal protein S6 kinase activity
Sequence:(RefSeq accession:NP_112369; substrate region highlighted if known)
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MPLAQLKEPW PLMELVPLDP ENGQASGEEA GLQPSKDEGI LKEISITHHV KAGSEKADPS
HFELLKVLGQ GSFGKVFLVR KVTRPDNGHL YAMKVLKKAT LKVRDRVRTK MERDILADVN
HPFVVKLHYA FQTEGKLYLI LDFLRGGDLF TRLSKEVMFT EEDVKFYLAE LALGLDHLHS
LGIIYRDLKP ENILLDEEGH IKLTDFGLSK EAIDHEKKAY SFCGTVEYMA PEVVNRQGHT
HSADWWSYGV LMFEMLTGSL PFQGKDRKET MTLILKAKLG MPQFLSTEAQ SLLRALFKRN
PANRLGSGPD GAEEIKRHIF YSTIDWNKLY RREIKPPFKP AVAQPDDTFY FDTEFTSRTP
RDSPGIPPSA GAHQLFRGFS FVATGLMEDD SKPRATQAPL HSVVQQLHGK NLVFSDGYIV
KETIGVGSYS VCKRCVHKAT NMEYAVKVID KSKRDPSEEI EILLRYGQHP NIITLKDVYD
DSKHVYLVTE LMRGGELLDK ILRQKFFSER EASFVLYTIS KTVEYLHSQG VVHRDLKPSN
ILYVDESGNP ECLRICDFGF AKQLRAENGL LMTPCYTANF VAPEVLKRQG YDEGCDIWSL
GVLLYTMLAG YTPFANGPSD TPEEILTRIS SGKFTLSGGN WNTVSETAKD LVSKMLHVDP
HQRLTAKQVL QHPWITQKDK LPQSQLSHQD LQLVKGGMAA TYSALSSSKP TPQLKPIESS
ILAQRRVRKL PSTTL
Records:
Category Evidence Reference
A Mutagenesis Cavet ME, Lehoux S, Berk BC., 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity., [12618428]
End of Record Details