ul_2060----
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PPBD protein
Gene name CRK( Description: v-crk sarcoma virus CT10 oncogene homolog (avian)-like. )
Synonyms Adapter molecule crk; p38
GO annotations GO_component: cytoplasm [PMID 10748058]; nucleus [PMID 10748058]
GO_function:protein binding [PMID 9788432] [PMID 9819391] [PMID 11278465] [PMID 16713569]; SH2 domain binding [PMID 9472046]; SH3/SH2 adaptor activity
GO_process: actin cytoskeleton organization and biogenesis [PMID 10748058]; cell motility; intracellular signaling cascade; regulation of transcription from RNA polymerase II promoter [PMID 10748058]
RefSeq accession NP_058431
SwissProt accession P46108
Substrate protein
Gene name PXN( Description: paxillin. )
Synonyms FLJ16691
GO annotations GO_component: cytoskeleton; microtubule associated complex [PMID 10840040]
GO_function:metal ion binding; protein binding [PMID 14688263]; vinculin binding [PMID 9054445]; zinc ion binding
GO_process: cell adhesion [PMID 10840040]; cell motility; cell-matrix adhesion; signal complex formation [PMID 9054445]; signal transduction [PMID 7534286]
RefSeq accession NP_002850
SwissProt accession P49023
GO Pathway:
GO:0007155     cell adhesion
Sequence:(RefSeq accession:NP_002850; substrate region highlighted if known)
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MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
TILDPLDQWQ PSGSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKFMA QGKTGSSSPP GGPPKPGSQL
DSMLGSLQSD LNKLGVATVA KGVCGACKKP IAGQVVTAMG KTWHPEHFVC THCQEEIGSR
NFFERDGQPY CEKDYHNLFS PRCYYCNGPI LDKVVTALDR TWHPEHFFCA QCGAFFGPEG
FHEKDGKAYC RKDYFDMFAP KCGGCARAIL ENYISALNTL WHPECFVCRE CFTPFVNGSF
FEHDGQPYCE VHYHERRGSL CSGCQKPITG RCITAMAKKF HPEHFVCAFC LKQLNKGTFK
EQNDKPYCQN CFLKLFC
Records:
Category Evidence Reference
A Inference Salgia R, Li JL, Lo SH, Brunkhorst B, Kansas GS, Sobhany ES, Sun Y, Pisick E, Hallek M, Ernst T, et al., Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by P210BCR/ABL, [7534286]
End of Record Details