ul_2070----
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PPBD protein
Gene name CRK( Description: v-crk sarcoma virus CT10 oncogene homolog (avian)-like. )
Synonyms Adapter molecule crk; p38
GO annotations GO_component: cytoplasm [PMID 10748058]; nucleus [PMID 10748058]
GO_function:protein binding [PMID 9788432] [PMID 9819391] [PMID 11278465] [PMID 16713569]; SH2 domain binding [PMID 9472046]; SH3/SH2 adaptor activity
GO_process: actin cytoskeleton organization and biogenesis [PMID 10748058]; cell motility; intracellular signaling cascade; regulation of transcription from RNA polymerase II promoter [PMID 10748058]
RefSeq accession NP_058431
SwissProt accession P46108
Substrate protein
Gene name Bcar1( Description: breast cancer anti-estrogen resistance 1. )
Synonyms Cas; Crkas; P130CAS
GO annotations GO_component: cytoplasm; focal adhesion; lamellipodium; membrane fraction; plasma membrane; ruffle
GO_function:protein binding; protein domain specific binding; signal transducer activity
GO_process: actin cytoskeleton organization and biogenesis; actin filament organization; B cell receptor signaling pathway; cell adhesion; cell division; cell migration; cell proliferation; epidermal growth factor receptor signaling pathway; G-protein coupled receptor protein signaling pathway; insulin receptor signaling pathway; integrin-mediated signaling pathway; nerve growth factor receptor signaling pathway; platelet-derived growth factor receptor signaling pathway; positive regulation of cell migration; regulation of apoptosis; regulation of cell growth; T cell receptor signaling pathway
RefSeq accession NP_037063
SwissProt accession
GO Pathway:
GO:0005515     protein binding
Sequence:(RefSeq accession:NP_037063; substrate region highlighted if known)
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MKYLVSVGAG PARRAGGLED VSWGPRVSRR PQSYRAARHV NESLPRSAFR VPAAHGASVT
PSAALGSGLP ETQPEAVCRG TEKPRFAEGC KPAASRDKNV LAKALYDNVA ESPDELSFRK
GDIMTVLERD TQGLDGWWLC SLHGRQGIVP GNRLKILVGM YDKKPAAPGP GPPATPPQPQ
PSLPQGVHTP VPPASQYSPM LPTAYQPQPD NVYLVPTPSK TQQGLYQAPG PNPQFQSPPA
KQTSTFSKQT PHHSFPSPAT DLYQVPPGPG SPAQDIYQVP PSAGTGHDIY QVPPSLDTRS
WEGTKPPAKV VVPTRVGQGY VYEASQAEQD EYDTPRHLLA PGSQDIYDVP PVRGLLPNQY
GQEVYDTPPM AVKGPNGRDP LLDVYDVPPS VEKGLPPSNH HSVYDVPPSV SKDVPDGPLL
REETYDVPPA FAKPKPFDPT RHPLILAAPP PDSPPAEDVY DVPPPAPDLY DVPPGLRRPG
PGTLYDVPRE RVLPPEVADG SVIDDGVYAV PPPAEREAPT DGKRLSASST GSTRSSQSAS
SLEVVVPGRE PLELEVAVET LARLQQGVST TVAHLLDLVG SASGPGGWRS TSEPQEPPVQ
DLKAAVAAVH GAVHELLEFA RSAVSSATHT SDRTLHAKLS RQLQKMEDVY QTLVVHGQVL
DSGRGGPGFT LDDLDRLVAC SRAVPEDAKQ LASFLHGNAS LLFRRTKAPG PGPEGSSSLH
LNPTDKASSI QSRPLPSPPK FTSQDSPDGQ YENSEGGWME DYDYVHLQGK EEFEKTQKEL
LEKGNIVRQG KGQLELQQLK QFERLEQEVS RPIDHDLANW TPAQPLVPGR TGGLGPSDRQ
LLLFYLEQCE ANLTTLTDAV DAFFTAVATN QPPKIFVAHS KFVILSAHKL VFIGDTLSRQ
AKAADVRSKV THYSNLLCDL LRGIVATTKA AALQYPSPSA AQDMVDRVKE LGHSTQQFRR
VLGQLAAA
Records:
Category Evidence Reference
A Inference Sakai R, Iwamatsu A, Hirano N, Ogawa S, Tanaka T, Mano H, Yazaki Y, Hirai H., A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner, [8070403]
End of Record Details