ul_2244----
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PPBD protein
Gene name CRK( Description: v-crk sarcoma virus CT10 oncogene homolog (avian)-like. )
Synonyms Adapter molecule crk; p38
GO annotations GO_component: cytoplasm [PMID 10748058]; nucleus [PMID 10748058]
GO_function:protein binding [PMID 9788432] [PMID 9819391] [PMID 11278465] [PMID 16713569]; SH2 domain binding [PMID 9472046]; SH3/SH2 adaptor activity
GO_process: actin cytoskeleton organization and biogenesis [PMID 10748058]; cell motility; intracellular signaling cascade; regulation of transcription from RNA polymerase II promoter [PMID 10748058]
RefSeq accession NP_058431
SwissProt accession P46108
Substrate protein
Gene name GAB1( Description: GRB2-associated binding protein 1. )
Synonyms
GO annotations GO_component:
GO_function:protein binding [PMID 9658397]; SH3/SH2 adaptor activity [PMID 8596638]
GO_process: cell proliferation [PMID 8596638]; epidermal growth factor receptor signaling pathway [PMID 8596638]; insulin receptor signaling pathway [PMID 8596638]
RefSeq accession NP_002030
SwissProt accession Q13480
Sequence:(RefSeq accession:NP_002030; substrate region highlighted if known)
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MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEEMNKWVRC ICDICGFNPT
EEDPVKPPGS SLQAPADLPL AINTAPPSTQ ADSSSATLPP PYQLINVPPH LETLGIQEDP
QDYLLLINCQ SKKPEPTRTH ADSAKSTSSE TDCNDNVPSH KNPASSQSKH GMNGFFQQQM
IYDSPPSRAP SASVDSSLYN LPRSYSHDVL PKVSPSSTEA DGELYVFNTP SGTSSVETQM
RHVSISYDIP PTPGNTYQIP RTFPEGTLGQ TSKLDTIPDI PPPRPPKPHP AHDRSPVETC
SIPRTASDTD SSYCIPTAGM SPSRSNTIST VDLNKLRKDA SSQDCYDIPR AFPSDRSSSL
EGFHNHFKVK NVLTVGSVSS EELDENYVPM NPNSPPRQHS SSFTEPIQEA NYVPMTPGTF
DFSSFGMQVP PPAHMGFRSS PKTPPRRPVP VADCEPPPVD RNLKPDRKVK PAPLEIKPLP
EWEELQAPVR SPITRSFARD SSRFPMSPRP DSVHSTTSSS DSHDSEENYV PMNPNLSSED
PNLFGSNSLD GGSSPMIKPK GDKQVEYLDL DLDSGKSTPP RKQKSSGSGS SVADERVDYV
VVDQQKTLAL KSTREAWTDG RQSTESETPA KSVK
Records:
Category Evidence Reference
A Inference Schaeper U, Gehring NH, Fuchs KP, Sachs M, Kempkes B, Birchmeier W., Coupling of Gab1 to c-Met, Grb2, and Shp2 mediates biological responses, [10871282]
End of Record Details