ul_2253----
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PPBD protein
Gene name CRK( Description: v-crk sarcoma virus CT10 oncogene homolog (avian)-like. )
Synonyms
GO annotations GO_component: cytoplasm [PMID 10748058]; nucleus [PMID 10748058]
GO_function:protein binding [PMID 9788432] [PMID 9819391] [PMID 11278465] [PMID 16713569]; SH2 domain binding [PMID 9472046]; SH3/SH2 adaptor activity
GO_process: actin cytoskeleton organization and biogenesis [PMID 10748058]; cell motility; intracellular signaling cascade; regulation of transcription from RNA polymerase II promoter [PMID 10748058]
RefSeq accession NP_058431
SwissProt accession Q96GA9
Substrate protein
Gene name MET( Description: met proto-oncogene (hepatocyte growth factor receptor). )
Synonyms AUTS9; EC 2.7.10.1; HGF receptor; HGF/SF receptor; HGFR; Met proto-oncogene tyrosine kinase; RCCP2; SF receptor; Scatter factor receptor; c-Met
GO annotations GO_component: basal plasma membrane [PMID 15314156]; integral to plasma membrane [PMID 1846706]; membrane
GO_function:ATP binding; hepatocyte growth factor receptor activity [PMID 10871856]; nucleotide binding; protein binding [PMID 11571281]; protein-tyrosine kinase activity; receptor activity; transferase activity
GO_process: cell proliferation [PMID 10871856]; development; protein amino acid phosphorylation; signal transduction [PMID 1846706]
RefSeq accession NP_000236
SwissProt accession P08581
Sequence:(RefSeq accession:NP_000236; substrate region highlighted if known)
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MKAPAVLAPG ILVLLFTLVQ RSNGECKEAL AKSEMNVNMK YQLPNFTAET PIQNVILHEH
HIFLGATNYI YVLNEEDLQK VAEYKTGPVL EHPDCFPCQD CSSKANLSGG VWKDNINMAL
VVDTYYDDQL ISCGSVNRGT CQRHVFPHNH TADIQSEVHC IFSPQIEEPS QCPDCVVSAL
GAKVLSSVKD RFINFFVGNT INSSYFPDHP LHSISVRRLK ETKDGFMFLT DQSYIDVLPE
FRDSYPIKYV HAFESNNFIY FLTVQRETLD AQTFHTRIIR FCSINSGLHS YMEMPLECIL
TEKRKKRSTK KEVFNILQAA YVSKPGAQLA RQIGASLNDD ILFGVFAQSK PDSAEPMDRS
AMCAFPIKYV NDFFNKIVNK NNVRCLQHFY GPNHEHCFNR TLLRNSSGCE ARRDEYRTEF
TTALQRVDLF MGQFSEVLLT SISTFIKGDL TIANLGTSEG RFMQVVVSRS GPSTPHVNFL
LDSHPVSPEV IVEHTLNQNG YTLVITGKKI TKIPLNGLGC RHFQSCSQCL SAPPFVQCGW
CHDKCVRSEE CLSGTWTQQI CLPAIYKVFP NSAPLEGGTR LTICGWDFGF RRNNKFDLKK
TRVLLGNESC TLTLSESTMN TLKCTVGPAM NKHFNMSIII SNGHGTTQYS TFSYVDPVIT
SISPKYGPMA GGTLLTLTGN YLNSGNSRHI SIGGKTCTLK SVSNSILECY TPAQTISTEF
AVKLKIDLAN RETSIFSYRE DPIVYEIHPT KSFISGGSTI TGVGKNLNSV SVPRMVINVH
EAGRNFTVAC QHRSNSEIIC CTTPSLQQLN LQLPLKTKAF FMLDGILSKY FDLIYVHNPV
FKPFEKPVMI SMGNENVLEI KGNDIDPEAV KGEVLKVGNK SCENIHLHSE AVLCTVPNDL
LKLNSELNIE WKQAISSTVL GKVIVQPDQN FTGLIAGVVS ISTALLLLLG FFLWLKKRKQ
IKDLGSELVR YDARVHTPHL DRLVSARSVS PTTEMVSNES VDYRATFPED QFPNSSQNGS
CRQVQYPLTD MSPILTSGDS DISSPLLQNT VHIDLSALNP ELVQAVQHVV IGPSSLIVHF
NEVIGRGHFG CVYHGTLLDN DGKKIHCAVK SLNRITDIGE VSQFLTEGII MKDFSHPNVL
SLLGICLRSE GSPLVVLPYM KHGDLRNFIR NETHNPTVKD LIGFGLQVAK GMKYLASKKF
VHRDLAARNC MLDEKFTVKV ADFGLARDMY DKEYYSVHNK TGAKLPVKWM ALESLQTQKF
TTKSDVWSFG VLLWELMTRG APPYPDVNTF DITVYLLQGR RLLQPEYCPD PLYEVMLKCW
HPKAEMRPSF SELVSRISAI FSTFIGEHYV HVNATYVNVK CVAPYPSLLS SEDNADDEVD
TRPASFWETS
Records:
Category Evidence Reference
A Inference Riordan SM, Lidder S, Williams R, Skouteris GG., The beta-subunit of the hepatocyte growth factor/scatter factor (HGF/SF) receptor phosphorylates and associates with CrkII: expression of CrkII enhances HGF/SF-induced mitogenesis, [10970810]
End of Record Details