ul_2300----
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PPBD protein
Gene name CRK( Description: v-crk sarcoma virus CT10 oncogene homolog (avian)-like. )
Synonyms Adapter molecule crk; p38
GO annotations GO_component: cytoplasm [PMID 10748058]; nucleus [PMID 10748058]
GO_function:protein binding [PMID 9788432] [PMID 9819391] [PMID 11278465] [PMID 16713569]; SH2 domain binding [PMID 9472046]; SH3/SH2 adaptor activity
GO_process: actin cytoskeleton organization and biogenesis [PMID 10748058]; cell motility; intracellular signaling cascade; regulation of transcription from RNA polymerase II promoter [PMID 10748058]
RefSeq accession NP_058431
SwissProt accession P46108
Substrate protein
Gene name Gab1( Description: growth factor receptor bound protein 2-associated protein 1. )
Synonyms AA408973; AW107238
GO annotations GO_component: cytoplasm
GO_function:protein binding; receptor activity; signal transducer activity
GO_process: activation of JNK activity; activation of MAPK activity; regulation of cell migration; response to oxidative stress; signal transduction
RefSeq accession NP_067331
SwissProt accession
Sequence:(RefSeq accession:NP_067331; substrate region highlighted if known)
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MSGGEVVCSG WLRKSPPEKK LKRYAWKRRW FVLRSGRLTG DPDVLEYYKN DHAKKPIRII
DLNLCQQVDA GLTFNKKEFE NSYIFDINTI DRIFYLVADS EEDMNKWVRC ICDICGFNPT
EEDPVKPLTG SSQAPVDSPF AISTAPASSQ MEASSVALPP PYQVISLPPH PDTLGLQDDP
QDYLLLINCQ SKKPEPNRTL FDSAKPTFSE TDCNDNVPSH QTPASSQSKH GMNGFFQQQM
MYDCPPSRLT SVSGESSLYN LPRSYSHDVL PKESPSSTEA DGELYTFNTP SGTAGVETQM
RHVSISYDIP PTPGNTYQIP RTFPESTLGQ SSKLDTIPDI PPPRPPKPHP THDRSPVETC
GVPRTASDTD SSYCIPPPAG MTPSRSNTIS TVDLNKLRKD ASSQDCYDIP RTFPSDRSSS
LEGFHSQYKI KSVLTAGGVS GEELDENYVP MNPNSPPRQH SGSFTEPIQE PNYVPMTPGT
FDFSSFGMQV PPPAHMGFRS SPKTPPRRPV PVADCEPPPV DRNLKPDRKV KPAPLDIKPL
SEWEELQAPV RSPITRSFAR DSSRFPMSPR PDSVHSTTSS SDSHDSEENY VPMNPNLSGE
DPNLFASNSL DGGSSPMNKP KGDKQVEYLD LDLDSGKSTP PRKQKSSGSG SSMADERVDY
VVVDQQKTLA LKSTREAWTD GRQSTESETP TKNVK
Records:
Category Evidence Reference
A Mutagenesis Sun H, Shen Y, Dokainish H, Holgado-Madruga M, Wong A, Ireton K., Host adaptor proteins Gab1 and CrkII promote InlB-dependent entry of Listeria monocytogenes, [15679846]
End of Record Details