ul_2308----
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PPBD protein
Gene name CRKL( Description: v-crk sarcoma virus CT10 oncogene homolog (avian)-like. )
Synonyms
GO annotations GO_component:
GO_function:protein binding [PMID 9788432]; protein-tyrosine kinase activity [PMID 8361759]; SH3/SH2 adaptor activity [PMID 8798523]
GO_process: cell motility; intracellular signaling cascade [PMID 8361759]; JNK cascade [PMID 8798523]; protein amino acid phosphorylation; Ras protein signal transduction [PMID 8798523]
RefSeq accession NP_005198
SwissProt accession P46109
Substrate protein
Gene name PXN( Description: paxillin. )
Synonyms FLJ16691
GO annotations GO_component: cytoskeleton; microtubule associated complex [PMID 10840040]
GO_function:metal ion binding; protein binding [PMID 14688263]; vinculin binding [PMID 9054445]; zinc ion binding
GO_process: cell adhesion [PMID 10840040]; cell motility; cell-matrix adhesion; signal complex formation [PMID 9054445]; signal transduction [PMID 7534286]
RefSeq accession NP_002850
SwissProt accession P49023
GO Pathway:
GO:0005070|KEGG:04510     SH3/SH2 adaptor activity|Focal adhesion
Sequence:(RefSeq accession:NP_002850; substrate region highlighted if known)
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MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG
TILDPLDQWQ PSGSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKFMA QGKTGSSSPP GGPPKPGSQL
DSMLGSLQSD LNKLGVATVA KGVCGACKKP IAGQVVTAMG KTWHPEHFVC THCQEEIGSR
NFFERDGQPY CEKDYHNLFS PRCYYCNGPI LDKVVTALDR TWHPEHFFCA QCGAFFGPEG
FHEKDGKAYC RKDYFDMFAP KCGGCARAIL ENYISALNTL WHPECFVCRE CFTPFVNGSF
FEHDGQPYCE VHYHERRGSL CSGCQKPITG RCITAMAKKF HPEHFVCAFC LKQLNKGTFK
EQNDKPYCQN CFLKLFC
Records:
Category Evidence Reference
A Mutagenesis Salgia R, Uemura N, Okuda K, Li JL, Pisick E, Sattler M, de Jong R, Druker B, Heisterkamp N, Chen LB, et al., CRKL links p210BCR/ABL with paxillin in chronic myelogenous leukemia cells, [7493940]
End of Record Details