ul_2445----
Record details: Hide
PPBD protein
Gene name CRKL( Description: v-crk sarcoma virus CT10 oncogene homolog (avian)-like. )
Synonyms
GO annotations GO_component:
GO_function:protein binding [PMID 9788432]; protein-tyrosine kinase activity [PMID 8361759]; SH3/SH2 adaptor activity [PMID 8798523]
GO_process: cell motility; intracellular signaling cascade [PMID 8361759]; JNK cascade [PMID 8798523]; protein amino acid phosphorylation; Ras protein signal transduction [PMID 8798523]
RefSeq accession NP_005198
SwissProt accession P46109
Substrate protein
Gene name SOCS3( Description: suppressor of cytokine signaling 3. )
Synonyms ATOD4; CIS-3; CIS3; Cish3; Cytokine-inducible SH2 protein 3; MGC71791; SOCS-3; SSI-3; SSI3; STAT-induced STAT inhibitor 3
GO annotations GO_component:
GO_function:protein kinase inhibitor activity [PMID 9266833]
GO_process: anti-apoptosis [PMID 9266833]; intracellular signaling cascade; JAK-STAT cascade [PMID 9266833]; negative regulation of signal transduction; regulation of cell growth
RefSeq accession NP_003946
SwissProt accession O14543
Sequence:(RefSeq accession:NP_003946; substrate region highlighted if known)
1
61
121
181
MVTHSKFPAA GMSRPLDTSL RLKTFSSKSE YQLVVNAVRK LQESGFYWSA VTGGEANLLL
SAEPAGTFLI RDSSDQRHFF TLSVKTQSGT KNLRIQCEGG SFSLQSDPRS TQPVPRFDCV
LKLVHHYMPP PGAPSFPSPP TEPSSEVPEQ PSAQPLPGSP PRRAYYIYSG GEKIPLVLSR
PLSSNVATLQ HLCRKTVNGH LDSYEKVTQL PGPIREFLDQ YDAPL
Records:
Category Evidence Reference
A Inference Sitko JC, Guevara CI, Cacalano NA., Tyrosine-phosphorylated SOCS3 interacts with the Nck and Crk-L adapter proteins and regulates Nck activation, [15173187]
End of Record Details