ul_2469----
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PPBD protein
Gene name CSK( Description: c-src tyrosine kinase. )
Synonyms C-SRC kinase; EC 2.7.10.2; MGC117393; Protein-tyrosine kinase CYL
GO annotations GO_component: cytoplasm [PMID 8890164]; plasma membrane [PMID 10790433]
GO_function:ATP binding; nucleotide binding; protein C-terminus binding [PMID 8890164]; protein-tyrosine kinase activity [PMID 1945408]; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 1945408]; regulation of progression through cell cycle [PMID 1377109]
RefSeq accession NP_004374
SwissProt accession P41240
Substrate protein
Gene name FYN( Description: FYN oncogene related to SRC, FGR, YES. )
Synonyms EC 2.7.10.2; MGC45350; Protooncogene Syn; SLK; SYN; p59-Fyn
GO annotations GO_component:
GO_function:ATP binding; identical protein binding [PMID 14993658]; non-membrane spanning protein tyrosine kinase activity [PMID 7822789]; nucleotide binding; protein binding [PMID 10790433]; protein-tyrosine kinase activity [PMID 1361685]; transferase activity
GO_process: calcium ion transport [PMID 7822789]; feeding behavior [PMID 8264796]; intracellular signaling cascade; learning [PMID 1361685]; protein amino acid phosphorylation [PMID 3526330] [PMID 7822789]; protein kinase cascade [PMID 1361685]; T cell receptor signaling pathway [PMID 7722293]
RefSeq accession NP_002028
SwissProt accession P06241
Sequence:(RefSeq accession:NP_002028; substrate region highlighted if known)
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481
MGCVQCKDKE ATKLTEERDG SLNQSSGYRY GTDPTPQHYP SFGVTSIPNY NNFHAAGGQG
LTVFGGVNSS SHTGTLRTRG GTGVTLFVAL YDYEARTEDD LSFHKGEKFQ ILNSSEGDWW
EARSLTTGET GYIPSNYVAP VDSIQAEEWY FGKLGRKDAE RQLLSFGNPR GTFLIRESET
TKGAYSLSIR DWDDMKGDHV KHYKIRKLDN GGYYITTRAQ FETLQQLVQH YSERAAGLCC
RLVVPCHKGM PRLTDLSVKT KDVWEIPRES LQLIKRLGNG QFGEVWMGTW NGNTKVAIKT
LKPGTMSPES FLEEAQIMKK LKHDKLVQLY AVVSEEPIYI VTEYMNKGSL LDFLKDGEGR
ALKLPNLVDM AAQVAAGMAY IERMNYIHRD LRSANILVGN GLICKIADFG LARLIEDNEY
TARQGAKFPI KWTAPEAALY GRFTIKSDVW SFGILLTELV TKGRVPYPGM NNREVLEQVE
RGYRMPCPQD CPISLHELMI HCWKKDPEER PTFEYLQSFL EDYFTATEPQ YQPGENL
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details