ul_2472----

Record details:

PPBD protein

Gene name	CSK( Description: c-src tyrosine kinase. )
Synonyms	C-SRC kinase; EC 2.7.10.2; MGC117393; Protein-tyrosine kinase CYL
GO annotations	GO_component: cytoplasm [PMID 8890164]; plasma membrane [PMID 10790433] GO_function:ATP binding; nucleotide binding; protein C-terminus binding [PMID 8890164]; protein-tyrosine kinase activity [PMID 1945408]; transferase activity GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 1945408]; regulation of progression through cell cycle [PMID 1377109]
RefSeq accession	NP_004374
SwissProt accession	P41240

Substrate protein

Gene name	LCK( Description: lymphocyte-specific protein tyrosine kinase. )
Synonyms	EC 2.7.10.2; LSK; Lymphocyte cell-specific protein-tyrosine kinase; T cell-specific protein-tyrosine kinase; YT16; p56-LCK; p56lck; pp58lck
GO annotations	GO_component: lipid raft [PMID 12732664]; pericentriolar material [PMID 7513706]; plasma membrane [PMID 15489916] GO_function:ATP binding; ATPase binding [PMID 15671290]; CD4 receptor binding [PMID 7486703]; CD8 receptor binding [PMID 2470098]; glycoprotein binding [PMID 7513706] [PMID 14625311] [PMID 15554700]; nucleotide binding; phosphoinositide 3-kinase binding [PMID 7504174]; protein C-terminus binding [PMID 16245368]; protein kinase binding [PMID 8618896]; protein serine/threonine phosphatase activity [PMID 8506364]; protein-tyrosine kinase activity [PMID 214242]; SH2 domain binding [PMID 7852312] [PMID 8794306]; transferase activity GO_process: caspase activation [PMID 16116473]; hemopoiesis [PMID 12884910]; induction of apoptosis [PMID 16116473]; intracellular signaling cascade [PMID 10358157]; positive regulation of T cell activation [PMID 8943371]; positive regulation of T cell receptor signaling pathway [PMID 12614355]; protein amino acid phosphorylation [PMID 3265417]; Ras protein signal transduction [PMID 10799545]; regulation of lymphocyte activation [PMID 7852312]; regulation of progression through cell cycle [PMID 8139546]; release of sequestered calcium ion into cytosol; response to drug [PMID 16116473]; T cell differentiation [PMID 1579166]; zinc ion homeostasis [PMID 11739864]
RefSeq accession	NP_005347
SwissProt accession	P06239

Sequence:(RefSeq accession:NP_005347; substrate region highlighted if known)

1
61
121
181
241
301
361
421
481

MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT YEGSNPPASP
LQDNLVIALH SYEPSHDGDL GFEKGEPLRI LEQSGEWWKA QSLTTGQEGF IPFNFVAKAN
SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS FLIRESESTA GSFSLSVRDF DQNQGEVVKH
YKIRNLDNGG FYISPRITFP GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV
PRETLKLVER LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL
VRLYAVVTQE PIYIITEYME NGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY
IHRDLRAANI LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY QLMRLCWKER
PEDRPTFDYL RSVLEDFFTA TEGQYQPQP

Records:

Category	Evidence	Reference
A	Inference	Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]

End of Record Details