ul_2490----
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PPBD protein
Gene name CSK( Description: c-src tyrosine kinase. )
Synonyms C-SRC kinase; EC 2.7.10.2; MGC117393; Protein-tyrosine kinase CYL
GO annotations GO_component: cytoplasm [PMID 8890164]; plasma membrane [PMID 10790433]
GO_function:ATP binding; nucleotide binding; protein C-terminus binding [PMID 8890164]; protein-tyrosine kinase activity [PMID 1945408]; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 1945408]; regulation of progression through cell cycle [PMID 1377109]
RefSeq accession NP_004374
SwissProt accession P41240
Substrate protein
Gene name PAG1( Description: phosphoprotein associated with glycosphingolipid microdomains 1. )
Synonyms CBP; Csk-binding protein; FLJ37858; MGC138364; PAG; Transmembrane adapter protein PAG; Transmembrane phosphoprotein Cbp
GO annotations GO_component: integral to membrane; membrane
GO_function:
GO_process: immune response
RefSeq accession NP_060910
SwissProt accession Q9NWQ8
Sequence:(RefSeq accession:NP_060910; substrate region highlighted if known)
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MGPAGSLLGS GQMQITLWGS LAAVAIFFVI TFLIFLCSSC DREKKPRQHS GDHENLMNVP
SDKEMFSRSV TSLATDAPAS SEQNGALTNG DILSEDSTLT CMQHYEEVQT SASDLLDSQD
STGKPKCHQS RELPRIPPES AVDTMLTARS VDGDQGLGME GPYEVLKDSS SQENMVEDCL
YETVKEIKEV AAAAHLEKGH SGKAKSTSAS KELPGPQTEG KAEFAEYASV DRNKKCRQSV
NVESILGNSC DPEEEAPPPV PVKLLDENEN LQEKEGGEAE ESATDTTSET NKRFSSLSYK
SREEDPTLTE EEISAMYSSV NKPGQLVNKS GQSLTVPEST YTSIQGDPQR SPSSCNDLYA
TVKDFEKTPN STLPPAGRPS EEPEPDYEAI QTLNREEEKA TLGTNGHHGL VPKENDYESI
SDLQQGRDIT RL
Records:
Category Evidence Reference
A Mutagenesis Brdicka T, Pavlistova D, Leo A, Bruyns E, Korinek V, Angelisova P, Scherer J, Shevchenko A, Hilgert I, Cerny J, Drbal K, Kuramitsu Y, Kornacker B, Horejsi V, Schraven B., Phosphoprotein associated with glycosphingolipid-enriched microdomains (PAG), a novel ubiquitously expressed transmembrane adaptor protein, binds the protein tyrosine kinase csk and is involved in regulation of T cell activation, [10790433]
A Inference Pfrepper KI, Marie-Cardine A, Simeoni L, Kuramitsu Y, Leo A, Spicka J, Hilgert I, Scherer J, Schraven B., Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein), [11433379]
End of Record Details