ul_2497----
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PPBD protein
Gene name CSK( Description: c-src tyrosine kinase. )
Synonyms C-SRC kinase; EC 2.7.10.2; MGC117393; Protein-tyrosine kinase CYL
GO annotations GO_component: cytoplasm [PMID 8890164]; plasma membrane [PMID 10790433]
GO_function:ATP binding; nucleotide binding; protein C-terminus binding [PMID 8890164]; protein-tyrosine kinase activity [PMID 1945408]; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 1945408]; regulation of progression through cell cycle [PMID 1377109]
RefSeq accession NP_004374
SwissProt accession P41240
Substrate protein
Gene name SIT1( Description: signaling threshold regulating transmembrane adaptor 1. )
Synonyms MGC125908; MGC125909; MGC125910; RP11-331F9.5; SHP2-interacting transmembrane adapter protein; SIT; Suppression-inducing transmembrane adapter 1; gp30/40
GO annotations GO_component: integral to plasma membrane [PMID 11433379]; plasma membrane [PMID 10209036]
GO_function:kinase binding [PMID 10209036]; protein binding [PMID 10209036]; SH2 domain binding [PMID 11433379]
GO_process: immune response; regulation of T cell activation [PMID 10209036]; signal transduction [PMID 10209036]
RefSeq accession NP_055265
SwissProt accession Q9Y3P8
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_055265; substrate region highlighted if known)
1
61
121
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MNQADPRLRA VCLWTLTSAA MSRGDNCTDL LALGIPSITQ AWGLWVLLGA VTLLFLISLA
AHLSQWTRGR SRSHPGQGRS GESVEEVPLY GNLHYLQTGR LSQDPEPDQQ DPTLGGPARA
AEEVMCYTSL QLRPPQGRIP GPGTPVKYSE VVLDSEPKSQ ASGPEPELYA SVCAQTRRAR
ASFPDQAYAN SQPAAS
Records:
Category Evidence Reference
A Mutagenesis Pfrepper KI, Marie-Cardine A, Simeoni L, Kuramitsu Y, Leo A, Spicka J, Hilgert I, Scherer J, Schraven B., Structural and functional dissection of the cytoplasmic domain of the transmembrane adaptor protein SIT (SHP2-interacting transmembrane adaptor protein), [11433379]
End of Record Details