ul_2498----
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PPBD protein
Gene name CSK( Description: c-src tyrosine kinase. )
Synonyms C-SRC kinase; EC 2.7.10.2; MGC117393; Protein-tyrosine kinase CYL
GO annotations GO_component: cytoplasm [PMID 8890164]; plasma membrane [PMID 10790433]
GO_function:ATP binding; nucleotide binding; protein C-terminus binding [PMID 8890164]; protein-tyrosine kinase activity [PMID 1945408]; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 1945408]; regulation of progression through cell cycle [PMID 1377109]
RefSeq accession NP_004374
SwissProt accession P41240
Substrate protein
Gene name DAG1( Description: dystroglycan 1 (dystrophin-associated glycoprotein 1). )
Synonyms 156DAG; A3a; AGRNR; DAG
GO annotations GO_component: actin cytoskeleton [PMID 1741056]; extracellular matrix (sensu Metazoa) [PMID 1741056]; integral to plasma membrane [PMID 8798547]; membrane fraction [PMID 8798547]; plasma membrane [PMID 1406935]
GO_function:calcium ion binding; laminin receptor activity; protein binding [PMID 9417121]
GO_process: muscle contraction [PMID 1406935]; protein complex assembly [PMID 1741056]
RefSeq accession NP_004384
SwissProt accession Q14118
Sequence:(RefSeq accession:NP_004384; substrate region highlighted if known)
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MRMSVGLSLL LPLWGRTFLL LLSVVMAQSH WPSEPSEAVR DWENQLEASM HSVLSDLHEA
VPTVVGIPDG TAVVGRSFRV TIPTDLIASS GDIIKVSAAG KEALPSWLHW DSQSHTLEGL
PLDTDKGVHY ISVSATRLGA NGSHIPQTSS VFSIEVYPED HSDLQSVRTA SPDPGEVVSS
ACAADEPVTV LTVILDADLT KMTPKQRIDL LHRMRSFSEV ELHNMKLVPV VNNRLFDMSA
FMAGPGNPKK VVENGALLSW KLGCSLNQNS VPDIHGVEAP AREGAMSAQL GYPVVGWHIA
NKKPPLPKRV RRQIHATPTP VTAIGPPTTA IQEPPSRIVP TPTSPAIAPP TETMAPPVRD
PVPGKPTVTI RTRGAIIQTP TLGPIQPTRV SEAGTTVPGQ IRPTMTIPGY VEPTAVATPP
TTTTKKPRVS TPKPATPSTD STTTTTRRPT KKPRTPRPVP RVTTKVSITR LETASPPTRI
RTTTSGVPRG GEPNQRPELK NHIDRVDAWV GTYFEVKIPS DTFYDHEDTT TDKLKLTLKL
REQQLVGEKS WVQFNSNSQL MYGLPDSSHV GKHEYFMHAT DKGGLSAVDA FEIHVHRRPQ
GDRAPARFKA KFVGDPALVL NDIHKKIALV KKLAFAFGDR NCSTITLQNI TRGSIVVEWT
NNTLPLEPCP KEQIAGLSRR IAEDDGKPRP AFSNALEPDF KATSITVTGS GSCRHLQFIP
VVPPRRVPSE APPTEVPDRD PEKSSEDDVY LHTVIPAVVV AAILLIAGII AMICYRKKRK
GKLTLEDQAT FIKKGVPIIF ADELDDSKPP PSSSMPLILQ EEKAPLPPPE YPNQSVPETT
PLNQDTMGEY TPLRDEDPNA PPYQPPPPFT VPMEGKGSRP KNMTPYRSPP PYVPP
Records:
Category Evidence Reference
A Peptide library Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP., Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins, [11724572]
End of Record Details