ul_2508----
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PPBD protein
Gene name EPHA3( Description: EPH receptor A3. )
Synonyms EC 2.7.10.1; ETK; ETK1; HEK; HEK4; TYRO4; Tyrosine-protein kinase TYRO4; Tyrosine-protein kinase receptor ETK1
GO annotations GO_component: integral to plasma membrane [PMID 1737782]; membrane
GO_function:ATP binding; ephrin receptor activity; nucleotide binding; protein-tyrosine kinase activity; receptor activity; transferase activity
GO_process: protein amino acid phosphorylation; signal transduction [PMID 1737782]; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_005224
SwissProt accession P29320
Substrate protein
Gene name RUFY1
Synonyms FYVE-finger protein EIP1; La-binding protein 1; Rab4-interacting protein; Zinc finger FYVE domain-containing protein 12
GO annotations GO_component: membrane
GO_function:lipid binding; metal ion binding; protein binding; zinc ion binding
GO_process: endocytosis; protein transport
RefSeq accession NP_001035542
SwissProt accession Q96T51
GO Pathway:
GO:0030100     regulation of endocytosis
Sequence:(RefSeq accession:NP_001035542; substrate region highlighted if known)
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MMEERANLMH MMKLSIKVLL QSALSLGRSL DADHAPLQQF FVVMEHCLKH GLKVKKSFIG
QNKSFFGPLE LVEKLCPEAS DIATSVRNLP ELKTAVGRGR AWLYLALMQK KLADYLKVLI
DNKHLLSEFY EPEALMMEEE GMVIVGLLVG LNVLDANLCL KGEDLDSQVG VIDFSLYLKD
VQDLDGGKEH ERITDVLDQK NYVEELNRHL SCTVGDLQTK IDGLEKTNSK LQEELSAATD
RICSLQEEQQ QLREQNELIR ERSEKSVEIT KQDTKVELET YKQTRQGLDE MYSDVWKQLK
EEKKVRLELE KELELQIGMK TEMEIAMKLL EKDTHEKQDT LVALRQQLEE VKAINLQMFH
KAQNAESSLQ QKNEAITSFE GKTNQVMSSM KQMEERLQHS ERARQGAEER SHKLQQELGG
RIGALQLQLS QLHEQCSSLE KELKSEKEQR QALQRELQHE KDTSSLLRME LQQVEGLKKE
LRELQDEKAE LQKICEEQEQ ALQEMGLHLS QSKLKMEDIK EVNQALKGHA WLKDDEATHC
RQCEKEFSIS RRKHHCRNCG HIFCNTCSSN ELALPSYPKP VRVCDSCHTL LLQRCSSTAS
Records:
Category Evidence Reference
A Mutagenesis Yang J, Kim O, Wu J, Qiu Y., Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking, [11877430]
End of Record Details