ul_2528----
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PPBD protein
Gene name FES( Description: feline sarcoma oncogene. )
Synonyms C-Fes; EC 2.7.10.2; FPS
GO annotations GO_component:
GO_function:ATP binding; nucleotide binding; protein-tyrosine kinase activity [PMID 6183005]; transferase activity
GO_process: cell proliferation [PMID 6264598]; development [PMID 6264598]; intracellular signaling cascade; protein amino acid phosphorylation [PMID 6183005]
RefSeq accession NP_001996
SwissProt accession P07332
Substrate protein
Gene name CDK6( Description: cyclin-dependent kinase 6. )
Synonyms EC 2.7.11.22; MGC59692; PLSTIRE; Serine/threonine-protein kinase PLSTIRE
GO annotations GO_component:
GO_function:ATP binding; nucleotide binding; protein binding [PMID 9150368] [PMID 15232106]; protein serine/threonine kinase activity; transferase activity
GO_process: cell cycle; cell division; cell proliferation [PMID 8114739]; G1 phase of mitotic cell cycle [PMID 8114739]; protein amino acid phosphorylation; regulation of progression through cell cycle [PMID 8114739]
RefSeq accession NP_001250
SwissProt accession Q00534
Sequence:(RefSeq accession:NP_001250; substrate region highlighted if known)
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MEKDGLCRAD QQYECVAEIG EGAYGKVFKA RDLKNGGRFV ALKRVRVQTG EEGMPLSTIR
EVAVLRHLET FEHPNVVRLF DVCTVSRTDR ETKLTLVFEH VDQDLTTYLD KVPEPGVPTE
TIKDMMFQLL RGLDFLHSHR VVHRDLKPQN ILVTSSGQIK LADFGLARIY SFQMALTSVV
VTLWYRAPEV LLQSSYATPV DLWSVGCIFA EMFRRKPLFR GSSDVDQLGK ILDVIGLPGE
EDWPRDVALP RQAFHSKSAQ PIEKFVTDID ELGKDLLLKC LTFNPAKRIS AYSALSHPYF
QDLERCKENL DSHLPPSQNT SELNTA
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details