ul_2533----
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PPBD protein
Gene name FES( Description: feline sarcoma oncogene. )
Synonyms C-Fes; EC 2.7.10.2; FPS
GO annotations GO_component:
GO_function:ATP binding; nucleotide binding; protein-tyrosine kinase activity [PMID 6183005]; transferase activity
GO_process: cell proliferation [PMID 6264598]; development [PMID 6264598]; intracellular signaling cascade; protein amino acid phosphorylation [PMID 6183005]
RefSeq accession NP_001996
SwissProt accession P07332
Substrate protein
Gene name Ptpn6( Description: protein tyrosine phosphatase, non-receptor type 6. )
Synonyms Hcph; Ptp1C; SHP-1; hcp; me; motheaten
GO annotations GO_component: cytoplasm
GO_function:phosphotyrosine binding; protein binding; protein tyrosine phosphatase activity
GO_process: cytokine and chemokine mediated signaling pathway; intracellular signaling cascade
RefSeq accession NP_038573
SwissProt accession
Sequence:(RefSeq accession:NP_038573; substrate region highlighted if known)
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MVRWFHRDLS GPDAETLLKG RGVPGSFLAR PSRKNQGDFS LSVRVDDQVT HIRIQNSGDF
YDLYGGEKFA TLTELVEYYT QQQGILQDRD GTIIHLKYPL NCSDPTSERW YHGHISGGQA
ESLLQAKGEP WTFLVRESLS QPGDFVLSVL NDQPKAGPGS PLRVTHIKVM CEGGRYTVGG
SETFDSLTDL VEHFKKTGIE EASGAFVYLR QPYYATRVNA ADIENRVLEL NKKQESEDTA
KAGFWEEFES LQKQEVKNLH QRLEGQRPEN KSKNRYKNIL PFDHSRVILQ GRDSNIPGSD
YINANYVKNQ LLGPDENSKT YIASQGCLDA TVNDFWQMAW QENTRVIVMT TREVEKGRNK
CVPYWPEVGT QRVYGLYSVT NSREHDTAEY KLRTLQISPL DNGDLVREIW HYQYLSWPDH
GVPSEPGGVL SFLDQINQRQ ESLPHAGPII VHCSAGIGRT GTIIVIDMLM ESISTKGLDC
DIDIQKTIQM VRAQRSGMVQ TEAQYKFIYV AIAQFIETTK KKLEIIQSQK GQESEYGNIT
YPPAVRSAHA KASRTSSKHK EEVYENVHSK SKKEEKVKKQ RSADKEKNKG SLKRK
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details