ul_2534----
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PPBD protein
Gene name FES( Description: feline sarcoma oncogene. )
Synonyms C-Fes; EC 2.7.10.2; FPS
GO annotations GO_component:
GO_function:ATP binding; nucleotide binding; protein-tyrosine kinase activity [PMID 6183005]; transferase activity
GO_process: cell proliferation [PMID 6264598]; development [PMID 6264598]; intracellular signaling cascade; protein amino acid phosphorylation [PMID 6183005]
RefSeq accession NP_001996
SwissProt accession P07332
Substrate protein
Gene name PTPRF( Description: protein tyrosine phosphatase, receptor type, F. )
Synonyms EC 3.1.3.48; FLJ43335; FLJ45062; FLJ45567; LAR; LAR protein; Leukocyte antigen related
GO annotations GO_component: integral to plasma membrane [PMID 2972792]; membrane
GO_function:hydrolase activity; protein binding; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity [PMID 8995282]
GO_process: cell adhesion [PMID 7665159]; protein amino acid dephosphorylation; transmembrane receptor protein tyrosine phosphatase signaling pathway [PMID 8995282]
RefSeq accession NP_569707
SwissProt accession P10586
Sequence:(RefSeq accession:NP_569707; substrate region highlighted if known)
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MVPLVPALVM LGLVAGAHGD SKPVFIKVPE DQTGLSGGVA SFVCQATGEP KPRITWMKKG
KKVSSQRFEV IEFDDGAGSV LRIQPLRVQR DEAIYECTAT NSLGEINTSA KLSVLEEEQL
PPGFPSIDMG PQLKVVEKAR TATMLCAAGG NPDPEISWFK DFLPVDPATS NGRIKQLRSG
ALQIESSEES DQGKYECVAT NSAGTRYSAP ANLYVRVRRV APRFSIPPSS QEVMPGGSVN
LTCVAVGAPM PYVKWMMGAE ELTKEDEMPV GRNVLELSNV VRSANYTCVA ISSLGMIEAT
AQVTVKALPK PPIDLVVTET TATSVTLTWD SGNSEPVTYY GIQYRAAGTE GPFQEVDGVA
TTRYSIGGLS PFSEYAFRVL AVNSIGRGPP SEAVRARTGE QAPSSPPRRV QARMLSASTM
LVQWEPPEEP NGLVRGYRVY YTPDSRRPPN AWHKHNTDAG LLTTVGSLLP GITYSLRVLA
FTAVGDGPPS PTIQVKTQQG VPAQPADFQA EVESDTRIQL SWLLPPQERI IMYELVYWAA
EDEDQQHKVT FDPTSSYTLE DLKPDTLYRF QLAARSDMGV GVFTPTIEAR TAQSTPSAPP
QKVMCVSMGS TTVRVSWVPP PADSRNGVIT QYSVAHEAVD GEDRGRHVVD GISREHSSWD
LVGLEKWTEY RVWVRAHTDV GPGPESSPVL VRTDEDVPSG PPRKVEVEPL NSTAVHVYWK
LPVPSKQHGQ IRGYQVTYVR LENGEPRGLP IIQDVMLAEA QETTISGLTP ETTYSVTVAA
YTTKGDGARS KPKIVTTTGA VPGRPTMMIS TTAMNTALLQ WHPPKELPGE LLGYRLQYCR
ADEARPNTID FGKDDQHFTV TGLHKGTTYI FRLAAKNRAG LGEEFEKEIR TPEDLPSGFP
QNLHVTGLTT STTELAWDPP VLAERNGRII SYTVVFRDIN SQQELQNITT DTRFTLTGLK
PDTTYDIKVR AWTSKGSGPL SPSIQSRTMP VEQVFAKNFR VAAAMKTSVL LSWEVPDSYK
SAVPFKILYN GQSVEVDGHS MRKLIADLQP NTEYSFVLMN RGSSAGGLQH LVSIRTAPDL
LPHKPLPASA YIEDGRFDLS MPHVQDPSLV RWFYIVVVPI DRVGGSMLTP RWSTPEELEL
DELLEAIEQG GEEQRRRRRQ AERLKPYVAA QLDVLPETFT LGDKKNYRGF YNRPLSPDLS
YQCFVLASLK EPMDQKRYAS SPYSDEIVVQ VTPAQQQEEP EMLWVTGPVL AVILIILIVI
AILLFKRKRT HSPSSKDEQS IGLKDSLLAH SSDPVEMRRL NYQTPGMRDH PPIPITDLAD
NIERLKANDG LKFSQEYESI DPGQQFTWEN SNLEVNKPKN RYANVIAYDH SRVILTSIDG
VPGSDYINAN YIDGYRKQNA YIATQGPLPE TMGDFWRMVW EQRTATVVMM TRLEEKSRVK
CDQYWPARGT ETCGLIQVTL LDTVELATYT VRTFALHKSG SSEKRELRQF QFMAWPDHGV
PEYPTPILAF LRRVKACNPL DAGPMVVHCS AGVGRTGCFI VIDAMLERMK HEKTVDIYGH
VTCMRSQRNY MVQTEDQYVF IHEALLEAAT CGHTEVPARN LYAHIQKLGQ VPPGESVTAM
ELEFKLLASS KAHTSRFISA NLPCNKFKNR LVNIMPYELT RVCLQPIRGV EGSDYINASF
LDGYRQQKAY IATQGPLAES TEDFWRMLWE HNSTIIVMLT KLREMGREKC HQYWPAERSA
RYQYFVVDPM AEYNMPQYIL REFKVTDARD GQSRTIRQFQ FTDWPEQGVP KTGEGFIDFI
GQVHKTKEQF GQDGPITVHC SAGVGRTGVF ITLSIVLERM RYEGVVDMFQ TVKTLRTQRP
AMVQTEDQYQ LCYRAALEYL GSFDHYAT
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, McGlade J, Olivier P, Pawson T, Bustelo XR, Barbacid M, Sabe H, Hanafusa H, Yi T, et al., Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav, [7511210]
End of Record Details