ul_2566----
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PPBD protein
Gene name FGR( Description: Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog. )
Synonyms C-FGR; EC 2.7.10.2; FLJ43153; MGC75096; P55-FGR; SRC2; c-fgr; c-src2; p55c-fgr; p58c-fgr
GO annotations GO_component:
GO_function:ATP binding; nucleotide binding; protein-tyrosine kinase activity [PMID 3003578]; transferase activity
GO_process: intracellular signaling cascade; protein amino acid phosphorylation [PMID 2995972]; response to virus [PMID 3003578]
RefSeq accession NP_001036212
SwissProt accession P09769
Substrate protein
Gene name RB1( Description: retinoblastoma 1 (including osteosarcoma). )
Synonyms OSRC; P105-RB; PP110; RB
GO annotations GO_component: chromatin [PMID 3657987]; nucleus [PMID 3413073] [PMID 3657987]
GO_function:androgen receptor binding [PMID 15572661]; kinase binding [PMID 16286473]; protein binding [PMID 7542657] [PMID 9395244] [PMID 9858607] [PMID 16286473]; transcription coactivator activity [PMID 15572661]; transcription factor activity [PMID 3657987]
GO_process: androgen receptor signaling pathway [PMID 15572661]; cell cycle checkpoint [PMID 10825186]; G1 phase [PMID 7542657]; M phase [PMID 7542657]; negative regulation of cell growth [PMID 7542657]; negative regulation of progression through cell cycle; negative regulation of protein kinase activity [PMID 9858607]; negative regulation of transcription from RNA polymerase II promoter [PMID 9491888]; positive regulation of transcription, DNA-dependent [PMID 15572661]; regulation of lipid kinase activity [PMID 16286473]; regulation of transcription, DNA-dependent [PMID 3413073]; transcription
RefSeq accession NP_000312
SwissProt accession P06400
Sequence:(RefSeq accession:NP_000312; substrate region highlighted if known)
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481
541
601
661
721
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841
901
MPPKTPRKTA ATAAAAAAEP PAPPPPPPPE EDPEQDSGPE DLPLVRLEFE ETEEPDFTAL
CQKLKIPDHV RERAWLTWEK VSSVDGVLGG YIQKKKELWG ICIFIARVDL DEMSFTLLSY
RKTYEISVHK FFNLLKEIDT STKVDNAMSR LLKKYDVLFA LFSKLERTCE LIYLTQPSSS
ISTEINSALV LKVSWITFLL AKGEVLQMED DLVISFQLML CVLDYFIKLS PPMLLKEPYK
TAVIPINGSP RTPRRGQNRS ARIAKQLEND TRIIEVLCKE HECNIDEVKN VYFKNFIPFM
NSLGLVTSNG LPEVENLSKR YEEIYLKNKD LDRRLFLDHD KTLQTDSIDS FETQRTPRKS
NLDEEVNIIP PHTPVRTVMN TIQQLMMILN SASDQPSENL ISYFNNCTVN PKESILKRVK
DIGYIFKEKF AKAVGQGCVE IGSQRYKLGV RLYYRVMESM LKSEEERLSI QNFSKLLNDN
IFHMSLLACA LEVVMATYSR STSQNLDSGT DLSFPWILNV LNLKAFDFYK VIESFIKAEG
NLTREMIKHL ERCEHRIMES LAWLSDSPLF DLIKQSKDRE GPTDHLESAC PLNLPLQNNH
TAADMYLSPV RSPKKKGSTT RVNSTANAET QATSAFQTQK PLKSTSLSLF YKKVYRLAYL
RLNTLCERLL SEHPELEHII WTLFQHTLQN EYELMRDRHL DQIMMCSMYG ICKVKNIDLK
FKIIVTAYKD LPHAVQETFK RVLIKEEEYD SIIVFYNSVF MQRLKTNILQ YASTRPPTLS
PIPHIPRSPY KFPSSPLRIP GGNIYISPLK SPYKISEGLP TPTKMTPRSR ILVSIGESFG
TSEKFQKINQ MVCNSDRVLK RSAEGSNPPK PLKKLRFDIE GSDEADGSKH LPGESKFQQK
LAEMTSTRTR MQKQKMNDSM DTSNKEEK
Records:
Category Evidence Reference
A Inference Songyang Z, Shoelson SE, Chaudhuri M, Gish G, Pawson T, Haser WG, King F, Roberts T, Ratnofsky S, Lechleider RJ, et al., SH2 domains recognize specific phosphopeptide sequences, [7680959]
End of Record Details