ul_2644----
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PPBD protein
Gene name FYN( Description: FYN oncogene related to SRC, FGR, YES. )
Synonyms EC 2.7.10.2; MGC45350; Protooncogene Syn; SLK; SYN; p59-Fyn
GO annotations GO_component:
GO_function:ATP binding; identical protein binding [PMID 14993658]; non-membrane spanning protein tyrosine kinase activity [PMID 7822789]; nucleotide binding; protein binding [PMID 10790433]; protein-tyrosine kinase activity [PMID 1361685]; transferase activity
GO_process: calcium ion transport [PMID 7822789]; feeding behavior [PMID 8264796]; intracellular signaling cascade; learning [PMID 1361685]; protein amino acid phosphorylation [PMID 3526330] [PMID 7822789]; protein kinase cascade [PMID 1361685]; T cell receptor signaling pathway [PMID 7722293]
RefSeq accession NP_002028
SwissProt accession P06241
Substrate protein
Gene name CD3E( Description: CD3e molecule, epsilon (CD3-TCR complex). )
Synonyms T3E; TCRE
GO annotations GO_component: external side of plasma membrane [PMID 11390434]; integral to plasma membrane [PMID 9485181]; plasma membrane [PMID 11390434]; T cell receptor complex [PMID 9485181]
GO_function:protein heterodimerization activity [PMID 9485181]; protein kinase binding [PMID 12110186]; receptor signaling complex scaffold activity [PMID 9886373]; SH3 domain binding [PMID 12110186]; T cell receptor binding [PMID 11186279]; transmembrane receptor activity [PMID 9485181]
GO_process: G-protein coupled receptor protein signaling pathway [PMID 8530500]; positive regulation of T cell proliferation [PMID 12110186]; protein complex assembly [PMID 9886373]; regulation of apoptosis [PMID 12567487]; signal complex formation [PMID 8490660]; T cell activation [PMID 12110186]
RefSeq accession NP_000724
SwissProt accession P07766
GO Pathway:
GO:0006468     protein amio acid phosphorylation
Sequence:(RefSeq accession:NP_000724; substrate region highlighted if known)
1
61
121
181
MQSGTHWRVL GLCLLSVGVW GQDGNEEMGG ITQTPYKVSI SGTTVILTCP QYPGSEILWQ
HNDKNIGGDE DDKNIGSDED HLSLKEFSEL EQSGYYVCYP RGSKPEDANF YLYLRARVCE
NCMEMDVMSV ATIVIVDICI TGGLLLLVYY WSKNRKAKAK PVTRGAGAGG RQRGQNKERP
PPVPNPDYEP IRKGQRDLYS GLNQRRI
Records:
Category Evidence Reference
A Inference Gauen LK, Zhu Y, Letourneur F, Hu Q, Bolen JB, Matis LA, Klausner RD, Shaw AS., Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif, [8196616]
End of Record Details