ul_2675----
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PPBD protein
Gene name FYN( Description: FYN oncogene related to SRC, FGR, YES. )
Synonyms EC 2.7.10.2; MGC45350; Protooncogene Syn; SLK; SYN; p59-Fyn
GO annotations GO_component:
GO_function:ATP binding; identical protein binding [PMID 14993658]; non-membrane spanning protein tyrosine kinase activity [PMID 7822789]; nucleotide binding; protein binding [PMID 10790433]; protein-tyrosine kinase activity [PMID 1361685]; transferase activity
GO_process: calcium ion transport [PMID 7822789]; feeding behavior [PMID 8264796]; intracellular signaling cascade; learning [PMID 1361685]; protein amino acid phosphorylation [PMID 3526330] [PMID 7822789]; protein kinase cascade [PMID 1361685]; T cell receptor signaling pathway [PMID 7722293]
RefSeq accession NP_002028
SwissProt accession P06241
Substrate protein
Gene name SCAP1
Synonyms SKAP-55; Src family-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa; pp55
GO annotations GO_component:
GO_function:protein binding [PMID 9195899]; protein-tyrosine kinase activity [PMID 9195899]; SH3/SH2 adaptor activity [PMID 9195899]
GO_process: immune response [PMID 9195899]; signal transduction [PMID 9195899]
RefSeq accession NP_003717
SwissProt accession O15268
GO Pathway:
GO:0050852     T cell receptor signaling pathway
GO:0006955     immune response
Sequence:(RefSeq accession:NP_003717; substrate region highlighted if known)
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MQAAALPEEI RWLLEDAEEF LAEGLRNENL SAVARDHRDH ILRGFQQIKA RYYWDFQPQG
GDIGQDSSDD NHSGTLGLSL TSDAPFLSDY QDEGMEDIVK GAQELDNVIK QGYLEKKSKD
HSFFGSEWQK RWCVVSRGLF YYYANEKSKQ PKGTFLIKGY SVRMAPHLRR DSKKESCFEL
TSQDRRSYEF TATSPAEARD WVDQISFLLK DLSSLTIPYE EDEEEEEKEE TYDDIDGFDS
PSCGSQCRPT ILPGSVGIKE PTEEKEEEDI YEVLPDEEHD LEEDESGTRR KGVDYASYYQ
GLWDCHGDQP DELSFQRGDL IRILSKEYNM YGWWVGELNS LVGIVPKEYL TTAFEVEER
Records:
Category Evidence Reference
A Inference Marie-Cardine A, Bruyns E, Eckerskorn C, Kirchgessner H, Meuer SC, Schraven B., Molecular cloning of SKAP55, a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes, [9195899]
A Mutagenesis Wu L, Yu Z, Shen SH., SKAP55 recruits to lipid rafts and positively mediates the MAPK pathway upon T cell receptor activation, [12171928]
End of Record Details