ul_2705----
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PPBD protein
Gene name FYN( Description: FYN oncogene related to SRC, FGR, YES. )
Synonyms EC 2.7.10.2; MGC45350; Protooncogene Syn; SLK; SYN; p59-Fyn
GO annotations GO_component:
GO_function:ATP binding; identical protein binding [PMID 14993658]; non-membrane spanning protein tyrosine kinase activity [PMID 7822789]; nucleotide binding; protein binding [PMID 10790433]; protein-tyrosine kinase activity [PMID 1361685]; transferase activity
GO_process: calcium ion transport [PMID 7822789]; feeding behavior [PMID 8264796]; intracellular signaling cascade; learning [PMID 1361685]; protein amino acid phosphorylation [PMID 3526330] [PMID 7822789]; protein kinase cascade [PMID 1361685]; T cell receptor signaling pathway [PMID 7722293]
RefSeq accession NP_002028
SwissProt accession P06241
Substrate protein
Gene name PTPN11( Description: protein tyrosine phosphatase, non-receptor type 11 (Noonan syndrome 1). )
Synonyms BPTP3; CFC; EC 3.1.3.48; MGC14433; NS1; PTP-1D; PTP-2C; PTP2C; Protein-tyrosine phosphatase 2C; SH-PTP2; SH-PTP3; SHP-2; SHP2; Shp2
GO annotations GO_component:
GO_function:hydrolase activity; non-membrane spanning protein tyrosine phosphatase activity [PMID 7681589]; protein binding [PMID 9658397] [PMID 10209036]
GO_process: intracellular signaling cascade; protein amino acid dephosphorylation; sensory perception of sound
RefSeq accession NP_002825
SwissProt accession Q06124
GO Pathway:
GO:0004317     protein-tyrosine kinase activity
Sequence:(RefSeq accession:NP_002825; substrate region highlighted if known)
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MTSRRWFHPN ITGVEAENLL LTRGVDGSFL ARPSKSNPGD FTLSVRRNGA VTHIKIQNTG
DYYDLYGGEK FATLAELVQY YMEHHGQLKE KNGDVIELKY PLNCADPTSE RWFHGHLSGK
EAEKLLTEKG KHGSFLVRES QSHPGDFVLS VRTGDDKGES NDGKSKVTHV MIRCQELKYD
VGGGERFDSL TDLVEHYKKN PMVETLGTVL QLKQPLNTTR INAAEIESRV RELSKLAETT
DKVKQGFWEE FETLQQQECK LLYSRKEGQR QENKNKNRYK NILPFDHTRV VLHDGDPNEP
VSDYINANII MPEFETKCNN SKPKKSYIAT QGCLQNTVND FWRMVFQENS RVIVMTTKEV
ERGKSKCVKY WPDEYALKEY GVMRVRNVKE SAAHDYTLRE LKLSKVGQGN TERTVWQYHF
RTWPDHGVPS DPGGVLDFLE EVHHKQESIM DAGPVVVHCS AGIGRTGTFI VIDILIDIIR
EKGVDCDIDV PKTIQMVRSQ RSGMVQTEAQ YRFIYMAVQH YIETLQRRIE EEQKSKRKGH
EYTNIKYSLA DQTSGDQSPL PPCTPTPPCA EMREDSARVY ENVGLMQQQK SFR
Records:
Category Evidence Reference
A Inference Tang H, Zhao ZJ, Huang XY, Landon EJ, Inagami T., Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in Madin-Darby canine kidney cells, [10212213]
End of Record Details