ul_2729----
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PPBD protein
Gene name FYN( Description: FYN oncogene related to SRC, FGR, YES. )
Synonyms EC 2.7.10.2; MGC45350; Protooncogene Syn; SLK; SYN; p59-Fyn
GO annotations GO_component:
GO_function:ATP binding; identical protein binding [PMID 14993658]; non-membrane spanning protein tyrosine kinase activity [PMID 7822789]; nucleotide binding; protein binding [PMID 10790433]; protein-tyrosine kinase activity [PMID 1361685]; transferase activity
GO_process: calcium ion transport [PMID 7822789]; feeding behavior [PMID 8264796]; intracellular signaling cascade; learning [PMID 1361685]; protein amino acid phosphorylation [PMID 3526330] [PMID 7822789]; protein kinase cascade [PMID 1361685]; T cell receptor signaling pathway [PMID 7722293]
RefSeq accession NP_002028
SwissProt accession P06241
Substrate protein
Gene name GRB10
Synonyms GRB10 adaptor protein; Insulin receptor-binding protein GRB-IR
GO annotations GO_component: cytoplasm [PMID 9006901]; plasma membrane [PMID 9006901]
GO_function:protein binding [PMID 8798570]; SH3/SH2 adaptor activity [PMID 9006901]
GO_process: cell-cell signaling [PMID 9006901]; insulin receptor signaling pathway [PMID 9006901]; intracellular signaling cascade
RefSeq accession NP_005302
SwissProt accession Q13322
Sequence:(RefSeq accession:NP_005302; substrate region highlighted if known)
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MALAGCPDSF LHHPYYQDKV EQTPRSQQDP AGPGLPAQSD RLANHQEDDV DLEALVNDMN
ASLESLYSAC SMQSDTVPLL QNGQHARSQP RASGPPRSIQ PQVSPRQRVQ RSQPVHILAV
RRLQEEDQQF RTSSLPAIPN PFPELCGPGS PPVLTPGSLP PSQAAAKQDV KVFSEDGTSK
VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELV VQVESTMASE
SKFLFRKNYA KYEFFKNPMN FFPEQMVTWC QQSNGSQTQL LQNFLNSSSC PEIQGFLHVK
ELGKKSWKKL YVCLRRSGLY CSTKGTSKEP RHLQLLADLE DSNIFSLIAG RKQYNAPTDH
GLCIKPNKVR NETKELRLLC AEDEQTRTCW MTAFRLLKYG MLLYQNYRIP QQRKALLSPF
STPVRSVSEN SLVAMDFSGQ TGRVIENPAE AQSAALEEGH AWRKRSTRMN ILGSQSPLHP
STLSTVIHRT QHWFHGRISR EESHRIIKQQ GLVDGLFLLR DSQSNPKAFV LTLCHHQKIK
NFQILPCEDD GQTFFSLDDG NTKFSDLIQL VDFYQLNKGV LPCKLKHHCI RVAL
Records:
Category Evidence Reference
A Mutagenesis Langlais P, Dong LQ, Hu D, Liu F., Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family, [10871840]
End of Record Details