ul_2735----
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PPBD protein
Gene name FYN( Description: FYN oncogene related to SRC, FGR, YES. )
Synonyms EC 2.7.10.2; MGC45350; Protooncogene Syn; SLK; SYN; p59-Fyn
GO annotations GO_component:
GO_function:ATP binding; identical protein binding [PMID 14993658]; non-membrane spanning protein tyrosine kinase activity [PMID 7822789]; nucleotide binding; protein binding [PMID 10790433]; protein-tyrosine kinase activity [PMID 1361685]; transferase activity
GO_process: calcium ion transport [PMID 7822789]; feeding behavior [PMID 8264796]; intracellular signaling cascade; learning [PMID 1361685]; protein amino acid phosphorylation [PMID 3526330] [PMID 7822789]; protein kinase cascade [PMID 1361685]; T cell receptor signaling pathway [PMID 7722293]
RefSeq accession NP_002028
SwissProt accession P06241
Substrate protein
Gene name Grlf1( Description: glucocorticoid receptor DNA binding factor 1. )
Synonyms 6430596G11Rik; AI841135; KIAA1722; mKIAA1722
GO annotations GO_component: actin cytoskeleton; cytoplasm; intracellular; nucleus
GO_function:DNA binding; GTP binding; GTPase activator activity; nucleotide binding; receptor activity
GO_process: cell cycle; eye development (sensu Mammalia); forebrain development; integrin-mediated signaling pathway; negative regulation of progression through cell cycle; neural tube closure; regulation of cell shape; regulation of transcription, DNA-dependent; signal transduction; small GTPase mediated signal transduction; transcription
RefSeq accession NP_766327
SwissProt accession
Sequence:(RefSeq accession:NP_766327; substrate region highlighted if known)
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MMMARKQDVR IPTYNISVVG LSGTEKEKGQ CGIGKSCLCN RFVRPSADEF HLDHTSVLST
SDFGGRVVNN DHFLYWGEVS RSLEDCVECK MHIVEQTEFI DDQTFQPHRS TALQPYIKRA
AATKLASAEK LMYFCTDQLG LEQDFEQKQM PDGKLLVDGF LLGIDVSRGM NRNFDDQLKF
VSNLYNQLAK TKKPIVVVLT KCDEGVERYI RDAHTFALSK KNLQVVETSA RSNVNVDLAF
STLVQLIDKS RGKTKIIPYF EALKQQSQQI ATAKDKYEWL VSRIVKNHNE NWPSVSRKMQ
ASPEYQDYVY LEGTQKAKKL FLQHIHRLKH EHIERRRKLY LAALPLAFEA LIPNLDEVDH
LSCIKAKKLL ETKPEFLKWF VVLEETPWDA TSHIDNMENE RIPFDLMDTV PAEQLYETHL
EKLRNERKRA EMRRAFKENL ETSPFITPGK PWEEARSFIM NEDFYQWLEE SVYMDIYGKH
QKQIIDRAKE EFQELLLEYS ELFYELELDA KPSKEKMGVI QDVLGEEQRF KALQKLQAER
DALILKHIHF VYHPTKETCP SCPACVDAKI EHLISSRFIR PSDRNQKNSL SDLNIDRINL
VILGKDGLAR ELANEIRALC TNDDKYVIDG KMYELSLRPI EGNVRLPVNS FQTPTFQPHG
CLCLYNSKES LSYVVESIEK SRESTLGRRD NHLVHLPLTL ILVNKRGDTS GETLHSLIQQ
GQQIASKLQC VFLDPASAGI GYGRNINEKQ ISQVLKGLLD SKRNLNLVSS TASIKDLADV
DLRIVMCLMC GDPFSADDVL SPVLQSQTCK SSHCGSSNSV LLELPIGLHK KRIELSVLSY
HSSFSIRKSR LVHGYIVFYS AKRKASLAML RAFLCEVQDI IPIQLVALTD GAIDVLDNDL
SREQLTEGEE IAQEIDGRFT SIPCSQPQHK LELFHPFFKD VVEKKNIIEA THMYDNVAEA
CSTTEEVFNS PRAGSPLCNS NLQDSEEDVE PPSYHLFRED ATLPSLSKDH SKFSMELEGN
DGLSFIMSNF ESKLNNKVPP PVKPKPPVHF DITKDLSYLD QGHREGQRKS MSSSPWMPQD
GFDPSDYAEP MDAVVKPRNE EENIYSVPHD STQGKIITIR NINKAQSNGS GNGSDSEMDT
SSLERGRKVS AVSKPVLYRT RCTRLGRFAS YRTSFSVGSD DELGPIRKKE EDQASQGYKG
DNAVIPYETD EDPRRRNILR SLRRNTKKPK PKPRPSITKA TWESNYFGVP LTTVVTPEKP
IPIFIERCIE YIEATGLSTE GIYRVSGNKS EMESLQRQFD QDHNLDLAEK DFTVNTVAGA
MKSFFSELPD PLVPYSMQID LVEAHKINDR EQKLHALKEV LKKFPKENHE VFKYVISHLN
KVSHNNKVNL MTSENLSICF WPTLMRPDFS SMDALTATRS YQTIIELFIQ QCPFFFYNRP
ISEPPGAAPG SPSAMAPTVP FLTSTPATSQ PSPPQSPPPT PQSPMQPLLS SQLQAEHTL
Records:
Category Evidence Reference
A Peptide library Wolf RM, Wilkes JJ, Chao MV, Resh MD., Tyrosine phosphorylation of p190 RhoGAP by Fyn regulates oligodendrocyte differentiation, [11536198]
End of Record Details