ul_2744----
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PPBD protein
Gene name FYN( Description: FYN oncogene related to SRC, FGR, YES. )
Synonyms EC 2.7.10.2; MGC45350; Protooncogene Syn; SLK; SYN; p59-Fyn
GO annotations GO_component:
GO_function:ATP binding; identical protein binding [PMID 14993658]; non-membrane spanning protein tyrosine kinase activity [PMID 7822789]; nucleotide binding; protein binding [PMID 10790433]; protein-tyrosine kinase activity [PMID 1361685]; transferase activity
GO_process: calcium ion transport [PMID 7822789]; feeding behavior [PMID 8264796]; intracellular signaling cascade; learning [PMID 1361685]; protein amino acid phosphorylation [PMID 3526330] [PMID 7822789]; protein kinase cascade [PMID 1361685]; T cell receptor signaling pathway [PMID 7722293]
RefSeq accession NP_002028
SwissProt accession P06241
Substrate protein
Gene name Kit( Description: kit oncogene. )
Synonyms Bs; CD117; Fdc; Ssm; Tr-kit; W; c-KIT
GO annotations GO_component: external side of plasma membrane; membrane
GO_function:ATP binding; kinase activity; nucleotide binding; protein binding; protein kinase activity; protein-tyrosine kinase activity; receptor activity; stem cell factor receptor activity; transferase activity; transmembrane receptor protein tyrosine kinase activity
GO_process: cell differentiation; cell proliferation; cellular physiological process; chemotaxis; cytokine and chemokine mediated signaling pathway; germ cell development; hemopoiesis; peptidyl-tyrosine phosphorylation; phosphorylation; pigmentation during development; protein amino acid autophosphorylation; protein amino acid phosphorylation; protein kinase cascade; response to radiation; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_066922
SwissProt accession
GO Pathway:
GO:0004713     protein-tyrosine kinase activity
Sequence:(RefSeq accession:NP_066922; substrate region highlighted if known)
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MRGARGAWDL LCVLLVLLRG QTATSQPSAS PGEPSPPSIH PAQSELIVEA GDTLSLTCID
PDFVRWTFKT YFNEMVENKK NEWIQEKAEA TRTGTYTCSN SNGLTSSIYV FVRDPAKLFL
VGLPLFGKED SDALVRCPLT DPQVSNYSLI ECDGKSLPTD LTFVPNPKAG ITIKNVKRAY
HRLCVRCAAQ RDGTWLHSDK FTLKVREAIK AIPVVSVPET SHLLKKGDTF TVVCTIKDVS
TSVNSMWLKM NPQPQHIAQV KHNSWHRGDF NYERQETLTI SSARVDDSGV FMCYANNTFG
SANVTTTLKV VEKGFINISP VKNTTVFVTD GENVDLVVEY EAYPKPEHQQ WIYMNRTSAN
KGKDYVKSDN KSNIRYVNQL RLTRLKGTEG GTYTFLVSNS DASASVTFNV YVNTKPEILT
YDRLINGMLQ CVAEGFPEPT IDWYFCTGAE QRCTTPVSPV DVQVQNVSVS PFGKLVVQSS
IDSSVFRHNG TVECKASNDV GKSSAFFNFA FKEQIQAHTL FTPLLIGFVV AAGAMGIIVM
VLTYKYLQKP MYEVQWKVVE EINGNNYVYI DPTQLPYDHK WEFPRNRLSF GKTLGAGAFG
KVVEATAYGL IKSDAAMTVA VKMLKPSAHL TEREALMSEL KVLSYLGNHM NIVNLLGACT
VGGPTLVITE YCCYGDLLNF LRRKRDSFIF SKQEEQAEAA LYKNLLHSTE PSCDSSNEYM
DMKPGVSYVV PTKTDKRRSA RIDSYIERDV TPAIMEDDEL ALDLDDLLSF SYQVAKAMAF
LASKNCIHRD LAARNILLTH GRITKICDFG LARDIRNDSN YVVKGNARLP VKWMAPESIF
SCVYTFESDV WSYGIFLWEL FSLGSSPYPG MPVDSKFYKM IKEGFRMVSP EHAPAEMYDV
MKTCWDADPL KRPTFKQVVQ LIEKQISDST KHIYSNLANC NPNPENPVVV DHSVRVNSVG
SSASSTQPLL VHEDA
Records:
Category Evidence Reference
A Mutagenesis Sette C, Paronetto MP, Barchi M, Bevilacqua A, Geremia R, Rossi P., Tr-kit-induced resumption of the cell cycle in mouse eggs requires activation of a Src-like kinase, [12374739]
End of Record Details