ul_2777----
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PPBD protein
Gene name GRAP( Description: GRB2-related adaptor protein. )
Synonyms MGC64880
GO annotations GO_component: cytoplasm [PMID 8647802]
GO_function:SH3/SH2 adaptor activity [PMID 8647802]
GO_process: cell-cell signaling [PMID 8647802]; intracellular signaling cascade; Ras protein signal transduction [PMID 8647802]
RefSeq accession NP_006604
SwissProt accession Q13588
Substrate protein
Gene name SHC1
Synonyms SH2 domain protein C1; Src homology 2 domain-containing-transforming protein C1
GO annotations GO_component: plasma membrane [PMID 14676841]
GO_function:insulin receptor binding [PMID 7537849] [PMID 7559478]; insulin-like growth factor receptor binding [PMID 7541045]; phospholipid binding [PMID 14676841]; protein binding [PMID 8491186]; transmembrane receptor protein tyrosine kinase adaptor protein activity [PMID 14676841]
GO_process: activation of MAPK activity [PMID 14676841]; intracellular signaling cascade; positive regulation of cell proliferation [PMID 14676841]; positive regulation of mitosis [PMID 14676841]; regulation of cell growth; regulation of epidermal growth factor receptor activity [PMID 1623525]
RefSeq accession NP_003020
SwissProt accession P29353
Sequence:(RefSeq accession:NP_003020; substrate region highlighted if known)
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MNKLSGGGGR RTRVEGGQLG GEEWTRHGSF VNKPTRGWLH PNDKVMGPGV SYLVRYMGCV
EVLQSMRALD FNTRTQVTRE AISLVCEAVP GAKGATRRRK PCSRPLSSIL GRSNLKFAGM
PITLTVSTSS LNLMAADCKQ IIANHHMQSI SFASGGDPDT AEYVAYVAKD PVNQRACHIL
ECPEGLAQDV ISTIGQAFEL RFKQYLRNPP KLVTPHDRMA GFDGSAWDEE EEEPPDHQYY
NDFPGKEPPL GGVVDMRLRE GAAPGAARPT APNAQTPSHL GATLPVGQPV GGDPEVRKQM
PPPPPCPAGR ELFDDPSYVN VQNLDKARQA VGGAGPPNPA INGSAPRDLF DMKPFEDALR
VPPPPQSVSM AEQLRGEPWF HGKLSRREAE ALLQLNGDFL VRESTTTPGQ YVLTGLQSGQ
PKHLLLVDPE GVVRTKDHRF ESVSHLISYH MDNHLPIISA GSELCLQQPV ERKL
Records:
Category Evidence Reference
A Peptide library Trub T, Frantz JD, Miyazaki M, Band H, Shoelson SE., The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling, [8995379]
End of Record Details