ul_2780----
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PPBD protein
Gene name GRAP( Description: GRB2-related adaptor protein. )
Synonyms MGC64880
GO annotations GO_component: cytoplasm [PMID 8647802]
GO_function:SH3/SH2 adaptor activity [PMID 8647802]
GO_process: cell-cell signaling [PMID 8647802]; intracellular signaling cascade; Ras protein signal transduction [PMID 8647802]
RefSeq accession NP_006604
SwissProt accession Q13588
Substrate protein
Gene name LAT( Description: linker for activation of T cells. )
Synonyms 36 kDa phospho-tyrosine adapter protein; LAT1; p36-38; pp36
GO annotations GO_component: immunological synapse [PMID 12646565]; integral to membrane [PMID 12646565]; lipid raft [PMID 14722116]; membrane
GO_function:protein binding [PMID 12646565] [PMID 14722116]; SH3/SH2 adaptor activity [PMID 12646565]
GO_process: calcium-mediated signaling [PMID 12646565]; immune response [PMID 9529333]; integrin-mediated signaling pathway [PMID 15100278]; intracellular signaling cascade [PMID 15100278]; mast cell degranulation; Ras protein signal transduction [PMID 12646565]; regulation of T cell activation [PMID 12646565]; signal transduction
RefSeq accession NP_055202
SwissProt accession O43561
GO Pathway:
GO:0050863     regulation of T cell activation
Sequence:(RefSeq accession:NP_055202; substrate region highlighted if known)
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MEEAILVPCV LGLLLLPILA MLMALCVHCH RLPGSYDSTS SDSLYPRGIQ FKRPHTVAPW
PPAYPPVTSY PPLSQPDLLP IPRSPQPLGG SHRTPSSRRD SDGANSVASY ENEGASGIRG
AQAGWGVWGP SWTRLTPVSL PPEPACEDAD EDEDDYHNPG YLVVLPDSTP ATSTAAPSAP
ALSTPGIRDS AFSMESIDDY VNVPESGESA EASLDGSREY VNVSQELHPG AAKTEPAALS
SQEAEEVEEE GAPDYENLQE LN
Records:
Category Evidence Reference
A Mutagenesis Perez-Villar JJ, Whitney GS, Sitnick MT, Dunn RJ, Venkatesan S, O'Day K, Schieven GL, Lin TA, Kanner SB., Phosphorylation of the linker for activation of T-cells by Itk promotes recruitment of Vav, [12186560]
End of Record Details