ul_2782----
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PPBD protein
Gene name GRAP2( Description: GRB2-related adaptor protein 2. )
Synonyms Adapter protein GRID; GADS; GADS protein; GRAP-2; GRB-2-like protein; GRB2L; GRBLG; GRBX; GRID; GRPL; GrbX; Grf-40; Grf40; Grf40 adapter protein; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; Mona; P38; SH3-SH2
GO annotations GO_component: cytoplasm [PMID 9878555]
GO_function:protein binding [PMID 12359715]; SH3/SH2 adaptor activity [PMID 9878555]
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 9878555]; cell-cell signaling [PMID 9878555]; intracellular signaling cascade; Ras protein signal transduction [PMID 9878555]
RefSeq accession NP_004801
SwissProt accession O75791
Substrate protein
Gene name CSF1R( Description: colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog. )
Synonyms C-FMS; CD115; CD115 antigen; CSF-1-R; CSFR; EC 2.7.10.1; FIM2; FMS; Fms proto-oncogene; c-fms
GO annotations GO_component: integral to plasma membrane [PMID 2421165]; plasma membrane [PMID 2421165]
GO_function:ATP binding; macrophage colony stimulating factor receptor activity [PMID 8981357]; nucleotide binding; receptor activity; transferase activity
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 8981357]; cell proliferation [PMID 8981357]; development [PMID 8981357]; protein amino acid phosphorylation; signal transduction [PMID 8981357]; transmembrane receptor protein tyrosine kinase signaling pathway
RefSeq accession NP_005202
SwissProt accession P07333
GO Pathway:
GO:0007275     development
Sequence:(RefSeq accession:NP_005202; substrate region highlighted if known)
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MGPGVLLLLL VATAWHGQGI PVIEPSVPEL VVKPGATVTL RCVGNGSVEW DGPPSPHWTL
YSDGSSSILS TNNATFQNTG TYRCTEPGDP LGGSAAIHLY VKDPARPWNV LAQEVVVFED
QDALLPCLLT DPVLEAGVSL VRVRGRPLMR HTNYSFSPWH GFTIHRAKFI QSQDYQCSAL
MGGRKVMSIS IRLKVQKVIP GPPALTLVPA ELVRIRGEAA QIVCSASSVD VNFDVFLQHN
NTKLAIPQQS DFHNNRYQKV LTLNLDQVDF QHAGNYSCVA SNVQGKHSTS MFFRVVESAY
LNLSSEQNLI QEVTVGEGLN LKVMVEAYPG LQGFNWTYLG PFSDHQPEPK LANATTKDTY
RHTFTLSLPR LKPSEAGRYS FLARNPGGWR ALTFELTLRY PPEVSVIWTF INGSGTLLCA
ASGYPQPNVT WLQCSGHTDR CDEAQVLQVW DDPYPEVLSQ EPFHKVTVQS LLTVETLEHN
QTYECRAHNS VGSGSWAFIP ISAGAHTHPP DEFLFTPVVV ACMSIMALLL LLLLLLLYKY
KQKPKYQVRW KIIESYEGNS YTFIDPTQLP YNEKWEFPRN NLQFGKTLGA GAFGKVVEAT
AFGLGKEDAV LKVAVKMLKS TAHADEKEAL MSELKIMSHL GQHENIVNLL GACTHGGPVL
VITEYCCYGD LLNFLRRKAE AMLGPSLSPG QDPEGGVDYK NIHLEKKYVR RDSGFSSQGV
DTYVEMRPVS TSSNDSFSEQ DLDKEDGRPL ELRDLLHFSS QVAQGMAFLA SKNCIHRDVA
ARNVLLTNGH VAKIGDFGLA RDIMNDSNYI VKGNARLPVK WMAPESIFDC VYTVQSDVWS
YGILLWEIFS LGLNPYPGIL VNSKFYKLVK DGYQMAQPAF APKNIYSIMQ ACWALEPTHR
PTFQQICSFL QEQAQEDRRE RDYTNLPSSS RSGGSGSSSS ELEEESSSEH LTCCEQGDIA
QPLLQPNNYQ FC
Records:
Category Evidence Reference
A Mutagenesis Bourette RP, Arnaud S, Myles GM, Blanchet JP, Rohrschneider LR, Mouchiroud G., Mona, a novel hematopoietic-specific adaptor interacting with the macrophage colony-stimulating factor receptor, is implicated in monocyte/macrophage development, [9857184]
End of Record Details