ul_2790----
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PPBD protein
Gene name GRAP2( Description: GRB2-related adaptor protein 2. )
Synonyms Adapter protein GRID; GADS; GADS protein; GRAP-2; GRB-2-like protein; GRB2L; GRBLG; GRBX; GRID; GRPL; GrbX; Grf-40; Grf40; Grf40 adapter protein; Growth factor receptor-binding protein; Hematopoietic cell-associated adapter protein GrpL; Mona; P38; SH3-SH2
GO annotations GO_component: cytoplasm [PMID 9878555]
GO_function:protein binding [PMID 12359715]; SH3/SH2 adaptor activity [PMID 9878555]
GO_process: antimicrobial humoral response (sensu Vertebrata) [PMID 9878555]; cell-cell signaling [PMID 9878555]; intracellular signaling cascade; Ras protein signal transduction [PMID 9878555]
RefSeq accession NP_004801
SwissProt accession O75791
Substrate protein
Gene name CD28( Description: CD28 molecule. )
Synonyms MGC138290; Tp44
GO annotations GO_component: external side of plasma membrane [PMID 11390434]; integral to plasma membrane [PMID 9784967]; membrane; plasma membrane [PMID 11390434]
GO_function:coreceptor activity [PMID 9784967]; identical protein binding [PMID 3159820]
GO_process: cell surface receptor linked signal transduction [PMID 9784967]; cytokine biosynthesis [PMID 8717514]; humoral immune response [PMID 8717514]; immune response; positive regulation of anti-apoptosis [PMID 8717514]; positive regulation of interleukin-2 biosynthesis [PMID 3875683]; positive regulation of mitosis [PMID 3159820]; positive regulation of protein biosynthesis [PMID 12028592]; positive regulation of T cell proliferation [PMID 3159820] [PMID 9784967]; positive regulation of viral genome replication [PMID 7492435]
RefSeq accession NP_006130
SwissProt accession P10747
GO Pathway:
GO:0007242     intracellular signaling cascade
Sequence:(RefSeq accession:NP_006130; substrate region highlighted if known)
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61
121
181
MLRLLLALNL FPSIQVTGNK ILVKQSPMLV AYDNAVNLSC KYSYNLFSRE FRASLHKGLD
SAVEVCVVYG NYSQQLQVYS KTGFNCDGKL GNESVTFYLQ NLYVNQTDIY FCKIEVMYPP
PYLDNEKSNG TIIHVKGKHL CPSPLFPGPS KPFWVLVVVG GVLACYSLLV TVAFIIFWVR
SKRSRLLHSD YMNMTPRRPG PTRKHYQPYA PPRDFAAYRS
Records:
Category Evidence Reference
A Mutagenesis Xia C, Bao Z, Tabassam F, Ma W, Qiu M, Hua S, Liu M., GCIP, a novel human grap2 and cyclin D interacting protein, regulates E2F-mediated transcriptional activity, [10801854]
A Mutagenesis Ellis JH, Ashman C, Burden MN, Kilpatrick KE, Morse MA, Hamblin PA., GRID: a novel Grb-2-related adapter protein that interacts with the activated T cell costimulatory receptor CD28, [10820259]
End of Record Details